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:: Volume 25, Issue 4 (winter 2015) ::
MEDICAL SCIENCES 2015, 25(4): 289-294 Back to browse issues page
Prevalence of reactivation of latent tuberculosis in the PPD positive patients who have undertaken assisted reproductive technique in Royan Institute
Mehrangiz Zangeneh1, Fatemeh Haji Hasan2, Narges Bagheri Lankarani3, Massomeh Jodmardi4, Seyed Davar Siadat5, Roya Shahbazi6
1- Department of Infectious Diseases, Islamic Azad University, Tehran Medical Branch, Tehran, Iran , zangeneh4@yahoo.com
2- 2 MSc of Midwifery, Royan Institute, Tehran, Iran
3- Epidemiologist, Royan Institute, Tehran, Iran
4- Researcher, Royan Institute, Tehran, Iran
5- Department of Microbiology, Pasteur Institute of Iran, Tehran, Iran
6- Medical Institute, Islamic Azad University, Tehran Medical Branch, Tehran, Iran
Abstract:   (6556 Views)

Background: Tuberculosis is second cause of death after HIV infection related to infectious diseases in the world. According to WHO reports, there are many risk factors for reactivation of tuberculosis infection. The aim of this study was to know if assisted reproductive techniques (ART) reactivate latent tuberculosis infection.

Materials and methods: In this retrospective cross sectional descriptive study that was made to evaluate the effect of ART on reactivation of latent tuberculosis. All patients with positive PPD test, TB in the past or patients who had sequels of TB from 2001 to 2012 were included in this study. Based on questionnaire, including demographics, kind of infertility treatment and active tuberculosis, one expert physician was asking some questions about sign and symptoms of tuberculosis.  If Patients had signs or symptoms of tuberculosis, they were visited by infectious disease specialist. Patients with tuberculosis were signed as reactivation of latent tuberculosis.

Results: Of 770 patients, 433 (56.2%) cases were only PPD positive, and 30.3% had PPD positive and signs of TB in the past. 81 (10.5%) patients did IUI, 126 (16.4%) ICSI, 43 (5.6%) IVF, 11 (1.4%) IVF/ICSI, and 7 (0/9%) ZIFT and 3 had donor of oocyts. There were 90 (11.7%) pregnancy, 24 (3.1%) deliveries, 30 (3.9%) abortions and 13 (1.7%) ectopic pregnancies, but there was only one case of reactivated TB in this study.

Conclusion: This study shows that patients with positive PPD do not need TB prophylaxis. For better result, we need a prospective study.

Keywords: PPD test, Assisted Reproductive Techniques,  Reactivation of latent tuberculosis.

Keywords: PPD test, Assisted Reproductive Techniques, Reactivation of latent tuberculosis
Full-Text [PDF 201 kb]   (9372 Downloads)    
Semi-pilot: Survey/Cross Sectional/Descriptive | Subject: Infectious Diseases
Received: 2015/02/8 | Accepted: 2015/05/20 | Published: 2015/12/20
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Zangeneh M, Haji Hasan F, Bagheri Lankarani N, Jodmardi M, Siadat S D, Shahbazi R. Prevalence of reactivation of latent tuberculosis in the PPD positive patients who have undertaken assisted reproductive technique in Royan Institute. MEDICAL SCIENCES 2015; 25 (4) :289-294
URL: http://tmuj.iautmu.ac.ir/article-1-1026-en.html


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Volume 25, Issue 4 (winter 2015) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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