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:: Volume 16, Issue 3 (Fall 2006) ::
MEDICAL SCIENCES 2006, 16(3): 125-128 Back to browse issues page
The study of the effects of formaldehyde injection on testicular tissue structure of mouse
Zahra Toutian1, Mohammadtaghi Sheybani, Simin Fazelipour, Mehdi Taghavi
1- , tootianz@ut.ac.ir
Abstract:   (17266 Views)
Background: Formaldehyde is one of the chemicals which are widely used in different places. Considering the fact that the usage of this chemical can induce a reduction on the motility and viability of spermatozoa and/or make them abnormal, a precise study on testicular tissue structure, producing spermatozoa, seems to be necessary because no accurate study has previously been carried out on this issue.
Materials and Methods: In this experimental-quantitative investigation, a total number of 30 mice were divided into four experimental and one control groups. In this study, formaldehyde has been injected intraperitoneally at different doses for a period of time of 40 days. In order to provide the tissue specimens, the mice were initially anesthetized and after removing the testes and tissue preparing processes, the hematoxylin and eosin staining method was used and the sections of testicular tissue were studied under light microscope.
Results: Comparison to the control group, disorganization in some seminiferous tubules, cellular irregularity and reduction in density of genital cells, increasing of intertubular spaces, and confusion of interstitial tissue, discoloration and vacuolization of leydig cell cytoplasm and also a thickness in basement membrane of spernatogenic epithelium were observed in the experimental groups.
 Conclusion: The results of this study revealed that injective formaldehyde could induce some changes in testicular tissue and also it could increase the risk of infertility.
Keywords: Formaldehyde, Testicular tissue, Mouse, Infertility, Sperm.
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Subject: Epidemiology
Received: 2006/09/6 | Published: 2006/09/15
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Toutian Z, Sheybani M, Fazelipour S, Taghavi M. The study of the effects of formaldehyde injection on testicular tissue structure of mouse. MEDICAL SCIENCES 2006; 16 (3) :125-128
URL: http://tmuj.iautmu.ac.ir/article-1-112-en.html

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Volume 16, Issue 3 (Fall 2006) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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