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Protective effect of L-carnitine and gallic acid in rat model of renal ischemia/reperfusion injury
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Sara Sadri1   , Mohammad Amin Edalatmanesh 2 |
1- Department of Biology
2- Department of Biology , amin.edalatmanesh@gmail.com |
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Abstract: (5441 Views) |
| Background: Acute kidney injury (AKI) often occurs as a result of ischemia-reperfusion. AKI is a major renal disease associated with high mortality rate. We investigated the renal protective effects of gallic acid and L-carnitine on the blood factors in rat model of renal ischemia-reperfusion.
Materials and methods: In this experimental study, forty male Wistar rats were randomly divided into 4 groups: controls, ischemia/reperfusion group (I/R), ischemia-reperfusion+L-carnitine (I/R+Lc, 500mg/kg), and ischemia/reperfusion + gallic acid (I/R+GA, 100mg/kg). Animals of the experimental groups were subjected to unilateral nephrectomy and received Gallic acid and L-carnitine for 14 days. Then, ischemia was induced by clamping the renal pedicle for 45 minutes. 72 h later, they were sacrificed, and the blood level of BUN, uric acid and creatinine were analyzed.
Results: The results showed a significant increase in BUN and creatinine of I/R group compared to the controls. Also, BUN and creatinine were significantly decreased in I/R+Lc and I/R+GA groups in comparison with I/R group. On other hand, blood level of uric acid was decreased in I/R+GA group compared to I/R group.
Conclusion: The results indicated that ischemia/reperfusion induced acute renal injury in rat model, and pretreatment with L-carnitine and gallic acid can prevent the kidney tissue damage from renal ischemia.
Keywords: Nephrectomy, Ischemia/Reperfusion, L-carnitine, Gallic acid, Rat. |
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| Keywords: Nephrectomy, Ischemia/Reperfusion, L-carnitine, Gallic acid, Rat. |
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Full-Text [PDF 445 kb]
(1181 Downloads)
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Semi-pilot: Experimental |
Subject:
Physiology
Received: 2017/02/28 | Accepted: 2017/04/30 | Published: 2017/09/20
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