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:: Volume 28, Issue 4 (winter 2018) ::
MEDICAL SCIENCES 2018, 28(4): 277-282 Back to browse issues page
Evaluation of melatonin effect on pelvic pain in women with endometriosis referred to affiliated hospitals to Tehran Medical Sciences of Islamic Azad University
Haniyeh Hoseinalizadeh 1, Shahla Cahichian * 2
1- Medical student, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2- Obstetrics & Gynecology, Minimally Invasive Techniques Research Center in Women, Tehran Medical Science, Islamic Azad University, Tehran, Iran,Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical Sciences, Tehran, Iran , shchaichian@gmail.com
Abstract:   (258 Views)
Background: Endometriosis is an estrogen dependent disease that causes endometriosis associated chronic pelvic pain (EACCP) in women with endometriosis via severe inflammatory reactions. Melatonin, as an antioxidant analgesic agent, seems to play a significant role in pain relief in endometriosis. This research was performed to investigate the efficacy of Melatonin on pelvic pain relief in women with endometriosis.  
Materials and methods: In this randomized triple-blind trial, 40 women with EACCP score≥7 participated in the study. The participants were randomized into melatonin and control groups. Melatonin group (n=20) received 5 mg melatonin for 8weeks. Control group (n=20) received placebo with the same characteristics as melatonin for the same duration. Pain score was recorded before treatment, and at the end of both the first and the second 4-week periods. Data were analyzed with SPSS.ver22.
Results: There was no statistically significant difference in dysmenorrhea pain score between control and treatment groups, at the beginning of study; while after 8weeks, pain score were significant different between control (5.86±0.99) and treatment groups (3.95±1.57).  There was no statistically significant difference in EACCP score, at the beginning, between control and treatment groups. After 8weeks, pain score was significantly higher in control group (5.57±1.02) compared to treatment group (3.57±1.60). Moreover, highly significant reduction in analgesic agents’ consumption was observed in treatment group compared to control group.
Conclusion: Regarding results, it is concluded that melatonin in comparison with placebo, considerably alleviates EACCP and dysmenorrhea, and reduces analgesic agents’ consumption.
 
Keywords: Endometriosis, Melatonin, Placebo, Pain.
Full-Text [PDF 258 kb]   (90 Downloads)    
Semi-pilot: Controlled/Randomized clinical trial | Subject: Gynecology
Received: 2018/03/13 | Accepted: 2018/07/2 | Published: 2018/12/23
References
1. Kennedy S, Bergqvist A, Chapron C, D'hooghe T, Dunselman G, Greb R, et al. ESHRE guideline for the diagnosis and treatment of endometriosis. Hum Reprod 2005;20:2698-704. [DOI:10.1093/humrep/dei135]
2. Mehedintu C, Plotogea M, Ionescu S, Antonovici M. Endometriosis still a challenge. J Med life. 2014;7:349-57.
3. Houston DE. Evidence for the risk of pelvic endometriosis by age, race and socioeconomic status. Epidemiol Rev 1984;6:167-91. [DOI:10.1093/oxfordjournals.epirev.a036270]
4. Schwertner A, Dos Santos CCC, Costa GD, Deitos A, de Souza A, de Souza ICC, et al. Efficacy of melatonin in the treatment of endometriosis: a phase II, randomized, double-blind, placebo-controlled trial. Pain. 2013;154:874-81. [DOI:10.1016/j.pain.2013.02.025]
5. Güney M, Oral B, Karahan N, Mungan T. Regression of endometrial explants in a rat model of endometriosis treated with melatonin. Fertil Steril 2008;89:934-42. [DOI:10.1016/j.fertnstert.2007.04.023]
6. Koc O, Gunduz B, Topcuoglu A, Bugdayci G, Yilmaz F, Duran B. Effects of pinealectomy and melatonin supplementation on endometrial explants in a rat model. Eur J Obstet Gynecol Reprod Biol 2010;153:72-6. [DOI:10.1016/j.ejogrb.2010.06.012]
7. Cetinkaya N, Attar R, Yildirim G, Ficicioglu C, Ozkan F, Yilmaz B, et al. The effects of different doses of melatonin treatment on endometrial implants in an oophorectomized rat endometriosis model. Arch Gynecol Obstet 2015;291:591-8. [DOI:10.1007/s00404-014-3466-3]
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Hoseinalizadeh H, Cahichian S. Evaluation of melatonin effect on pelvic pain in women with endometriosis referred to affiliated hospitals to Tehran Medical Sciences of Islamic Azad University. MEDICAL SCIENCES. 2018; 28 (4) :277-282
URL: http://tmuj.iautmu.ac.ir/article-1-1487-en.html


Volume 28, Issue 4 (winter 2018) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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