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:: Volume 29, Issue 1 (spring 2019) ::
MEDICAL SCIENCES 2019, 29(1): 27-36 Back to browse issues page
Effect of kind of exercise training on gene expression of β3-ARs and A2ARs receptors of brown adipose tissue in obese male rats
Shohre Sharifian *1, Ramin Shabani2 , Mohammad Ali Azarbayjani3, Alireza Elmieh2
1- PhD Candidate of Exercise Physiology, Department of Physical Education and Sport Sciences, Faculty of Humanities, Rasht Branch, Islamic Azad University, Rasht, Iran
2- Department of Physical Education and Sport Sciences, Faculty of Humanities, Rasht Branch, Islamic Azad University, Rasht, Iran
3- Department of Physical Education and Sport Sciences, Faculty of Sport Sciences, Central Tehran Branch, Islamic Azad University, Tehran, Iran
Abstract:   (108 Views)
Background: The aim of present study was to investigate the effect of a period of endurance training and high intensity intermittent training on gene expression of β3-Adrenergic (β3-ARs) and A2A (A2ARs) receptors of brown adipose tissue in obese male Wistar rats.
Materials and methods: In an experimental trial, 15 male Wistar rats were randomly divided into three groups, including endurance training group (n=5), high intensity intermittent training group (n=5) and control group (n=5). The training protocol included 5 sessions per week for 12 weeks. The gene expression of β3-Adrenergic and A2ARs were examined by qRT- PCR. The Kruskal-Wallis was used to analysis the data and significant level was set at p<0.05.
Results: There was no significant difference in gene expression of β3-ARs among groups (p=0.097), but endurance training caused the significant increase in gene expression of A2ARs compared to control group (p=0.030). The weight did not show any significant difference among groups (p>0.05).
Conclusion: Our results showed that endurance training induced significant enhance in gene expression of A2ARs of brown adipose tissue. This result can be due to suitable intensity and during of this training on A2ARs. According to results of this study, it is concluded that endurance training prevents high fat diet induced obesity.
Keywords: Brown adipose tissue, Endurance training, High intensity intermittent training, High fat diet
Full-Text [PDF 447 kb]   (65 Downloads)    
Semi-pilot: Experimental | Subject: Physiology
Received: 2018/05/26 | Accepted: 2018/08/26 | Published: 2019/03/11
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Sharifian S, Shabani R, Azarbayjani M A, Elmieh A. Effect of kind of exercise training on gene expression of β3-ARs and A2ARs receptors of brown adipose tissue in obese male rats . MEDICAL SCIENCES. 2019; 29 (1) :27-36
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Volume 29, Issue 1 (spring 2019) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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