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:: Volume 29, Issue 1 (spring 2019) ::
MEDICAL SCIENCES 2019, 29(1): 48-55 Back to browse issues page
Evaluation of serum levels of antioxidant trace elements, zinc, copper, selenium and manganese, in children with acute lymphoblastic leukemia before treatment
Mehrnaz Keshavarzi 1 , Fariba Faraji * 2, Monireh Movahedi 3
1- MSc of Biochemistry, Department of Biochemistry, Faculty of Biology, Tehran North Branch, Islamic Azad University, Tehran, Iran
2- Department of Biochemistry, Faculty of Medicine, Tehran Medical sciences, Islamic Azad University, Tehran, Iran , faraji_fariba@hotmail.com
3- Department of Biochemistry, Faculty of biology, Tehran North Branch, Islamic Azad University, Tehran, Iran
Abstract:   (53 Views)
Background: Reactive oxygen species (ROS) can induce carcinogenesis via DNA injury. Antioxidants participate in cell protection against harmful influence of oxidative stress. The aim of the present study was to assess the levels of antioxidant elements, including Zn, Cu, Se and Mn, in serum of children with acute lymphoblastic leukemia before treatment.
Materials and methods: In this study, 20 children just diagnosed ALL before chemotherapy (mean age, 6.6±4.6) compared to 20 healthy controls (mean age, 10.3±2.7). Concentration of the elements were measured with atomic absorption spectroscopy
Results: serum levels of Mn were significantly lower in acute leukemia than in controls (P=0.03), while Cu was significantly elevated (P <0.0001). There were no significant difference regarding Zn and Se between two groups (P =0.07 and P =0.35, respectively).
Conclusion: Based on obtained results, changes of serum level of these antioxidants could likely have biological role in initiation or progression of leukemia.  Further studies are needed to clarify the role of these factors in pathogenesis of acute leukemia
Keywords: Antioxidant trace elements, Acute lymphoblastic leukemia.
Full-Text [PDF 357 kb]   (16 Downloads)    
Semi-pilot: Survey/Cross Sectional/Descriptive | Subject: Cilinical Biochemistry
Received: 2018/07/15 | Accepted: 2018/09/16 | Published: 2019/03/11
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Keshavarzi M, Faraji F, Movahedi M. Evaluation of serum levels of antioxidant trace elements, zinc, copper, selenium and manganese, in children with acute lymphoblastic leukemia before treatment . MEDICAL SCIENCES. 2019; 29 (1) :48-55
URL: http://tmuj.iautmu.ac.ir/article-1-1530-en.html


Volume 29, Issue 1 (spring 2019) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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