[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
About the Journal
Editorial Board
Aims& Scopes
Journal News
Articles archive::
Current Issue
All Issues
For Authors::
Call for Papers
Submission Instruction
Submission Form
For Reviewers::
Reviewers Section
Registration::
Registration Information
Registration Form
Contact us::
Contact Information
Contact us
Site Facilities::
Site map
Search contents
FAQ
Top 10 contents
Inform to friends
Webmail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 30, Issue 1 (spring 2020) ::
MEDICAL SCIENCES 2020, 30(1): 33-39 Back to browse issues page
Preparation and evaluation of oxytocin SLNs as semi-finished product for nasal drops formulation
Seyyedeh Mahsa Alavi1 , Solmaz Ghaffari 2, Sommayyeh Nasiripour3
1- Pharmacy student, Faculty of Pharmacy, Tehran Medical Science, Islamic Azad University, Tehran, Iran
2- , ghaffari.s@iaups.ac.ir
3- Department of clinical pharmacy, Iran University of Medical Sciences, Tehran, Iran
Abstract:   (2830 Views)
Background: Oxytocin is a peptide hormone that increases the secretion of milk, especially after normal delivery. Due to the properties of this peptide hormone, it seems that changing the route of use and changing the release pattern can create a longer duration of action of the drug. Solid lipid nanoparticles (SLNs) are a candidate to achieve these goals, which can be used as a non-invasive method with the possibility of induction of postpartum breastfeeding. In this study, we tried to design new drug delivery system using nanotechnology to change route of administration and prolong the administration intervals in order to induction of milk secretion especially among mothers with Cesarean section.
Materials and methods: In this study, different SLNs were designed by changing many variables and all designed SLNs were evaluated in vitro. The mean particle size, zeta potential, loaded drug value, and drug release pattern were evaluated. Nanoparticles were freeze dried to increase stability.
Results: The amount of drug loaded in the selected nanoparticles was reported to be 82%. The study of drug release showed that after 72 hours, the rate of drug release reaches 80%.
Conclusion: Based on results, loaded peptide value, and drug release pattern was in a reasonable quantity. The optimum SLNs were freeze dried to increase the stability. The particles could be suitable candidate for preparing nasal drop of oxytocin to achieve the desired aims of the study.
Keywords: Oxytocin, Solid lipid nanoparticles (SLNs), Freeze drying, Stearic acid, Tween.
Full-Text [PDF 346 kb]   (2840 Downloads)    
Semi-pilot: Experimental | Subject: Pharmacology
Received: 2019/05/15 | Accepted: 2019/06/9 | Published: 2020/04/15
References
1. 1. Fewtrell MS, Loh KL, Blake A, Ridout DA, Hawdon J. Randomised, double blind trial of oxytocin nasal spray in mothers expressing breast milk for preterm infants. Arch Dis Child Fetal Neonatal Ed 2006;91:F169-74. [DOI:10.1136/adc.2005.081265]
2. Ruis H, Rolland R, Doesburg W, Broeders G, Corbey R. Oxytocin enhances onset of lactation among mothers delivering prematurely. Send to Br Med J 1981;283:340-2. [DOI:10.1136/bmj.283.6287.340]
3. Ochekpe N, Olorunfemi P, Ngwuluka N. Nanotechnology and drug delivery, Part 2: Nanostructures for drug delivery. Trop J Pharm Res 2009: 8: 275-287. [DOI:10.4314/tjpr.v8i3.44547]
4. Madan JR, Khude PA, Dua k. Development and evalution of solid lipid nano particles of mometasone furoare for topical delivery. Int J Pharm Investig 2014; 4: 60-4. [DOI:10.4103/2230-973X.133047]
5. Patidar A, Thakur DS, Kumar P, Verma J. A review on novel lipid based nanocarriers. Int J Pharm Sci 2010; 2: 30-35.
6. Attama AA, Momoh MA, Builders PF. Lipid nanoparticulate drug delivery systems: a revolution in dosage form design and development. In: Sezar AD, Editor. Pharmacology, toxicology and pharmaceutical science. Croatia: InTech open Access Publisher; 2012.
7. Elnaggar YS, El-Massik MA, Abdallah OY. Fabrication, appraisal, and transdermal permeation of sildenafil citrate-loaded nanostructured lipid carriers versus solid lipid nanoparticles. Int J Nanomedicine 2011;6:3195-205. [DOI:10.2147/IJN.S25825]
8. Kaur J, Singh G, Saini S, Rana A. Innivation growth in developing new methods for formulation solid lipid nanoparticles and microparticles. J Drug Deliv Therap 2012; 2:55-59. [DOI:10.22270/jddt.v2i5.295]
9. Waghmare A, Grampurohit N, Gadhave M, Gaikwad D, Jadhav S. Solid lipid nanoparticles: a promising drug delivery system. Int Res J Pharm 2012; 3: 100-107.
10. Malenka RC, Nestler EJ, Hyman SE. Neuropeptides. In: Sydor A, Brown RY, Editors. Molecular neuropharmacology: a foundation for clinical neuroscience. 2nd ed. New York: McGraw-Hill Medical; 2009.
11. Müller RH, Mäder K, Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art. Eur J Pharm Biopharm 2000;50:161-77. [DOI:10.1016/S0939-6411(00)00087-4]
12. Varshosaz J, Ghaffari S, Khoshayand MR, Atyabi F, Azarmi S, Kobarfard F. Development and optimization of solid lipid nanoparticles of amikacin by central composite design. J Liposome Res 2010;20:97-104. [DOI:10.3109/08982100903103904]
13. Ghaffari S, Varshosaz J, Saadat A, Atyabi F. Stability and antimicrobial effect of amikacin-loaded solid lipid nanoparticles. Int J Nanomed 2011;6:35-43. [DOI:10.2147/IJN.S13671]
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Alavi S M, Ghaffari S, Nasiripour S. Preparation and evaluation of oxytocin SLNs as semi-finished product for nasal drops formulation. MEDICAL SCIENCES 2020; 30 (1) :33-39
URL: http://tmuj.iautmu.ac.ir/article-1-1739-en.html
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 30, Issue 1 (spring 2020) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
Persian site map - English site map - Created in 0.05 seconds with 37 queries by YEKTAWEB 4660