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:: Volume 31, Issue 3 (Fall 2021) ::
MEDICAL SCIENCES 2021, 31(3): 299-306 Back to browse issues page
Effect of high-intensity interval training and Aloe vera consumption on serum adiponectin and beta cells function in diabetic male rats
Mahtab Sabzparvar1 , Shahin Riyahi Malayeri 2, Behzad Divkan3
1- MSc of Exercise Physiology, Department of Physical Education & Sport Sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran
2- Assistant Professor of Exercise Physiology, Department of physical education & sport sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran. , shahinriyahi@yahoo.com
3- Assistant Professor of Sport Management, Department of physical education & sport sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran
Abstract:   (2125 Views)
Background: Exercise training and the use of medicinal plants are helpful in the prevention and treatment of diabetes. The purpose of this study was to evaluate effect of eight-week high-intensity interval training and Aloe vera consumption on serum adiponectin and beta cells function in diabetic male rats.
Materials and methods: In this experimental study, 32 diabetic Wistar rats with STZ (weight of 240-260 grams and an average age of 12 weeks) were randomly divided into four groups, including the “control group”, the “training group”, the “supplement group” and the “training + supplement group”. Training group was exposed to high-intensity interval training with %90 VO2max intensity for 8 weeks and 5 sessions per week for 2 to 6 minutes per session. Supplement group received 300 mg of Aloe vera daily for 8 weeks, five times a week. Data were analyzed using one-way ANOVA.
Results: Eight weeks of high intensity interval training with Aloe vera supplementation resulted in a significant increase in adiponectin and insulin in diabetic male rats (P<0.05). But there was no significant difference in glucose and beta cell function (P>0.05).
Conclusion: According to the findings of the present research, it seems that high intensity interval training along with Aloe vera supplementation may help to increase adiponectin and insulin and also improve diabetes control.
Keywords: Adiponectin, Aloe vera, Diabetes, Interval training, Beta cells function.
Full-Text [PDF 323 kb]   (1094 Downloads)    
Semi-pilot: Experimental | Subject: Physiology
Received: 2020/09/28 | Accepted: 2021/02/20 | Published: 2021/09/1
References
1. Retnakaran R, Hanley AJ, Raif N, Hirning CR, Connelly PW, Sermer M, Kahn SE, Zinman B. Adiponectin and beta cell dysfunction in gestational diabetes: pathophysiological implications. Diabetologia. 2005 May;48(5):993-1001. Epub 2005 Mar 19. PubMed PMID: 15778860. [DOI:10.1007/s00125-005-1710-x]
2. Bergman RN, Finegood DT, Kahn SE. The evolution of beta-cell dysfunction and insulin resistance in type 2 diabetes. Eur J Clin Invest. 2002 Jun;32 Suppl 3:35-45. Review. PubMed PMID: 12028373. [DOI:10.1046/j.1365-2362.32.s3.5.x]
3. Berg AH, Combs TP, Scherer PE. ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab. 2002 Mar;13(2):84-9. Review. PubMed PMID: 11854024. [DOI:10.1016/S1043-2760(01)00524-0]
4. Aleidi S, Issa A, Bustanji H, Khalil M, Bustanji Y. Adiponectin serum levels correlate with insulin resistance in type 2 diabetic patients. Saudi Pharm J. 2015 Jul;23(3):250-6. doi: 10.1016/j.jsps.2014.11.011. Epub 2014 Dec 9. PMID: 26106273; PMCID: PMC4475813. Ohashi K, Shibata R, Murohara T, Ouchi N. Role of anti-inflammatory adipokines in obesity-related diseases.Trends Endocrinol Metab 2014; 25(7): 348-55. [DOI:10.1016/j.jsps.2014.11.011]
5. Scheideler M, Herzig S, Georgiadi A. Endocrine and autocrine/paracrine modulators of brown adipose tissue mass and activity as novel therapeutic strategies against obesity and type 2 diabetes. Horm Mol Biol Clin Investig. 2017 Aug 29;31(2). doi: 10.1515/hmbci-2017-0043. Review. PubMed PMID: 28850545. [DOI:10.1515/hmbci-2017-0043]
6. Andersson DP, Laurencikiene J, Acosta JR, Rydén M, Arner P. Circulating and Adipose Levels of Adipokines Associated with Insulin Sensitivity in Nonobese Subjects with Type 2 Diabetes. J Clin Endocrinol Metab. 2016 Oct;101(10):3765-3771. doi: 10.1210/jc.2016-1883. Epub 2016 Aug 8. PMID: 27501281; PMCID: PMC5052350. [DOI:10.1210/jc.2016-1883]
7. Yamauchi, T., Kamon, J., Waki, H. et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7, 941-946 (2001). https://doi.org/10.1038/90984 [DOI:10.1038/90984.]
8. Ghaderpanahi M, Fakhrzadeh H, Sharifi F, Badamchizade Z, Mirarefin M, Ebrahim RP, Ghotbi S, Nouri M, Larijani B. Association of physical activity with risk of type 2 diabetes. Iran J Public Health. 2011;40(1):86-93. Epub 2011 Mar 31. PMID: 23113060; PMCID: PMC3481723.
9. Boutcher SH. High-intensity intermittent exercise and fat loss. J Obes. 2011; 2011:868305. doi: 10.1155/2011/868305. Epub 2010 Nov 24. PMID: 21113312; PMCID: PMC2991639. [DOI:10.1155/2011/868305]
10. Simpson KA, Singh MA. Effects of exercise on adiponectin: a systematic review. Obesity (Silver Spring). 2008 Feb;16(2):241-56. doi: 10.1038/oby.2007.53. Review.PubMed PMID: 18239630. [DOI:10.1038/oby.2007.53]
11. Francois ME, Little JP. Effectiveness and safety of high-intensity interval training in patients with type 2 diabetes. Diabetes Spectr. 2015 Jan;28(1):39-44. doi: 10.2337/diaspect.28.1.39. PMID: 25717277; PMCID: PMC4334091. [DOI:10.2337/diaspect.28.1.39]
12. Patel H, Alkhawam H, Madanieh R, Shah N, Kosmas CE, Vittorio TJ. Aerobic vs anaerobic exercise training effects on the cardiovascular system. World J Cardiol. 2017 Feb 26;9(2):134-138. doi: 10.4330/wjc.v9.i2.134. PMID: 28289526; PMCID: PMC5329739. [DOI:10.4330/wjc.v9.i2.134]
13. Shing CM, Webb JJ, Driller MW, Williams AD, Fell JW. Circulating adiponectin concentration and body composition are altered in response to high-intensity interval training. J Strength Cond Res. 2013 Aug;27(8):2213-8. doi:10.1519/JSC.0b013e31827e1644. PubMed PMID: 23222083. [DOI:10.1519/JSC.0b013e31827e1644]
14. Lee SH, Hong HR, Han TK, Kang HS. Aerobic training increases the expression of adiponectin receptor genes in the peripheral blood mononuclear cells of young men. Biol Sport. 2015 Sep;32(3):181-6. doi: 10.5604/20831862.1150298. Epub 2015 Apr 24. PMID: 26424919; PMCID: PMC4577554. [DOI:10.5604/20831862.1150298]
15. Leggate M, Carter WG, Evans MJ, Vennard RA, Sribala-Sundaram S, Nimmo MA. Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males. J Appl Physiol (1985). 2012 Apr;112(8):1353-60. doi: 10.1152/japplphysiol.01080.2011. Epub 2012 Jan 19. PMID: 22267387; PMCID: PMC3331586. [DOI:10.1152/japplphysiol.01080.2011]
16. Choudhury H, Pandey M, Hua CK, Mun CS, Jing JK, Kong L, Ern LY, Ashraf NA, Kit SW, Yee TS, Pichika MR, Gorain B, Kesharwani P. An update on natural compounds in the remedy of diabetes mellitus: A systematic review. J Tradit Complement Med. 2017 Nov 29;8(3):361-376. doi: 10.1016/j.jtcme.2017.08.012. PMID: 29992107 [DOI:10.1016/j.jtcme.2017.08.012]
17. PMCID: PMC6035310. Rajasekaran S, Ravi K, Sivagnanam K, Subramanian S. Beneficial effects of aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes. Clin Exp Pharmacol Physiol 2006;33(3):232-7. [DOI:10.1111/j.1440-1681.2006.04351.x]
18. Surjushe A, Vasani R, Saple DG. Aloe vera: a short review. Indian J Dermatol. 2008;53(4):163-6. doi: 10.4103/0019-5154.44785. PMID: 19882025; PMCID: PMC2763764. [DOI:10.4103/0019-5154.44785]
19. Alinejad-Mofrad S, Foadoddini M, Saadatjoo SA, Shayesteh M. Improvement of glucose and lipid profile status with Aloe vera in pre-diabetic subjects: a randomized controlled-trial. J Diabetes Metab Disord. 2015 Apr 9; 14:22. doi: 10.1186/s40200-015-0137-2. PMID: 25883909; PMCID: PMC4399423. [DOI:10.1186/s40200-015-0137-2]
20. Thomas C, Bishop D, Moore-Morris T, Mercier J. Effects of high-intensity training on MCT1, MCT4, and NBC expressions in rat skeletal muscles: influence of chronic metabolic alkalosis. Am J Physiol Endocrinol Metab. 2007 Oct;293(4):E916-22. Epub 2007 Jul 3. PubMed PMID: 17609257. [DOI:10.1152/ajpendo.00164.2007]
21. Erfani MN, Bahrami M, Morovvati H, Najafzade H. Study the protective effect of Aloe Vera's on histological and histometric changes in testis of diabetic rats. Iran Veterinary J 2013; 9(2); 78-87. (Persian).
22. Singh B, Saxena A. Surrogate markers of insulin resistance: A review. World J Diabetes. 2010 May 15;1(2):36-47. doi: 10.4239/wjd. v1.i2.36. PMID: 21537426; PMCID: PMC3083884. [DOI:10.4239/wjd.v1.i2.36]
23. Rahman MM, Kwon HS, Kim MJ, Go HK, Oak MH, Kim DH. Melatonin supplementation plus exercise behavior ameliorate insulin resistance, hypertension and fatigue in a rat model of type 2 diabetes mellitus. Biomed Pharmacother. 2017 Aug [DOI:10.1016/j.biopha.2017.05.035]
24. 92:606-614. doi: 10.1016/j.biopha.2017.05.035. Epub 2017 Jun 1. PubMed PMID:28578257. [DOI:10.1016/j.biopha.2017.05.035]
25. Huang H, Iida KT, Sone H, Yokoo T, Yamada N, Ajisaka R. The effect of exercise training on adiponectin receptor expression in KKAy obese/diabetic mice. J Endocrinol. 2006 Jun;189(3):643-53. PubMed PMID: 16731794. [DOI:10.1677/joe.1.06630]
26. Kraemer RR, Castracane VD. Exercise and humoral mediators of peripheral energy balance: ghrelin and adiponectin. Exp Biol Med (Maywood). 2007 Feb;232(2):184-94. Review. PubMed PMID: 17259325.
27. Fatouros IG, Tournis S, Leontsini D, Jamurtas AZ, Sxina M, Thomakos P, et al. Leptin and adiponectin responses in overweight inactive elderly following resistance training and detraining are intensity related. J Clin Endocrinol Metab. 2005 Nov;90(11):5970-7. Epub 2005 Aug 9. PubMed PMID: 16091494. [DOI:10.1210/jc.2005-0261]
28. Kelly AS, Steinberger J, Olson TP, Dengel DR. In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children. Metabolism. 2007 Jul;56(7):1005-9. PubMed PMID: 17570265. [DOI:10.1016/j.metabol.2007.03.009]
29. Zarekar M, Saghebjoo M, Foadodini M, Hedayati M. Combined Effect of Aerobic Training and Pistacia Athlantica Extract on GLUT-4 Protein Expression and Muscle Glycogen in Diabetic Rats. Iranian Journal of Endocrinology and Metabolism. 2014; 16 (4) :245-253. (Persian).
30. Mohammadi R, Matin Homaee H, Azarbayjani M, Baesi, K. he Effect of 12-Week Resistance Training n Cardiac Hypertrophy,Glucose Level, Insulin, and Insulin Resistance Index in STZ-Induced Diabetic Rats. Qom Univ Med Sci J 2017;11(2):38-45. (Persian).
31. Friedenreich CM, Neilson HK, Woolcott CG, McTiernan A, Wang Q, Ballard-Barbash R, Jones CA, Stanczyk FZ, Brant RF, Yasui Y, Irwin ML, Campbell KL, McNeely ML, Karvinen KH, Courneya KS. Changes in insulin resistance indicators, IGFs, and adipokines in a year-long trial of aerobic exercise in postmenopausal women.Endocr Relat Cancer. 2011 Jun 8;18(3):357-69. doi: 10.1530/ERC-10-0303. Print2011 Jun. PubMed PMID: 21482635; PubMed Central PMCID: PMC3111235. [DOI:10.1530/ERC-10-0303]
32. Stanford KI, Goodyear LJ. Exercise and type 2 diabetes: molecular mechanisms regulating glucose uptake in skeletal muscle. Adv Physiol Educ. 2014 Dec;38(4):308-14. doi: 10.1152/advan.00080.2014. PMID: 25434013; PMCID: PMC4315445. [DOI:10.1152/advan.00080.2014]
33. Martin LJ, Woo JG, Daniels SR, Goodman E, Dolan LM. The relationships of adiponectin with insulin and lipids are strengthened with increasing adiposity. J Clin Endocrinol Metab. 2005 Jul;90(7):4255-9. doi: 10.1210/jc.2005-0019. Epub 2005 May 3. PMID: 15870125; PMCID: PMC4313924. [DOI:10.1210/jc.2005-0019]
34. Eizadi M, Ravasi A A, Soori R, Baesi K, Choubineh S. Effect of three months aerobic training on TCF7L2 expression in pancreatic tissue in type 2 diabetes rats induced by streptozotocin- nicotinamide. Feyz. 2017; 21 (1) :1-8. (Persian). [DOI:10.17795/ajmb-34014]
35. Salehi O R, Hoseini A. The Effects of Endurance Trainings on Serum BDNF and Insulin Levels in Streptozotocin-Induced Diabetic Rats. Shafayeh Khatam 2017; 5 (2) :52-61. (Persian). [DOI:10.18869/acadpub.shefa.5.2.52]
36. Chahardoli M, Mahmoodi M, Hajizadeh M, Khoramdel Azad H, Khoshdel A, Mirzaei M. Effect of Aloe Vera Hydroalcoholic Extract on Blood Glucose, Serum Insulin and the Key Enzymes in Metabolic Pathways of Glycolysis and Gluconeogenesis in Hepatocytes of Type 1 Diabetic Rats. JRUMS. 2015; 13 (8) :669-682
37. Mahmudzadeh T, Saghebjoo M, Seghatol Eslami A, Hedayati M. Effect of aerobic training and pistacia atlantica extract consumption on pancreatic β-cells function in streptozotocin-induced diabetic rats. Iranian journal of Diabetes and Metabolism 2014; 13(3). (Persian).
38. Eizadi M, Bahboudi L, Zahedmanesh F, Afsharmand Z.Effect of Acute andChronic Exercise on Beta-Cell Function in Diabetic Patients. Knowledge & Health 2012;6(4): 15-19. (Persian).
39. Wang C, Guan Y, Yang J. Cytokines in the Progression of Pancreatic β-Cell Dysfunction. Int J Endocrinol. 2010; 2010:515136. doi: 10.1155/2010/515136. Epub 2010 Nov 14. PubMed PMID: 21113299; PubMed Central PMCID: PMC2989452.
40. de Salles BF, Simão R, Fleck SJ, Dias I, Kraemer-Aguiar LG, Bouskela E.Effects of resistance training on cytokines. Int J Sports Med. 2010 [DOI:10.1055/s-0030-1251994]
41. Jul;31(7):441-50. doi: 10.1055/s-0030-1251994. Epub 2010 Apr 29. Review. PubMed PMID: 20432196. [DOI:10.1055/s-0030-1251994]
42. Salehi I, Mohammadi M, Farajnia S, Gaderi Sophi F, Badalzadeh R, Vatankhah AM. Effect of Regular Swimming on Oxidative Stress and Atherogenic Index in Blood of Diabetic Male Rats. Sci J Hamdan Univ Med Sci 2007; 14; 29- 35. [In Persian]
43. Bergman RN, Finegood DT, Kahn SE. The evolution of beta-cell dysfunction and insulin resistance in type 2 diabetes. Eur J Clin Invest 2002;32:35-45. [DOI:10.1046/j.1365-2362.32.s3.5.x]
44. Berg AH, Combs TP, Scherer PE. ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab. 2002;13:84-9. Riyahi Malayeri S, Azadniya A, Rasaee M J. Effect of Eight-week of High Intensity Interval Training and Resveratrol Intake on serum Adiponectin and Resistin in Type 2 Diabetic rats. IJDLD 2019; 18 :8-1. [In Persian] [DOI:10.1016/S1043-2760(01)00524-0]
45. Scheideler M, Herzig S, Georgiadi A. Endocrine and autocrine/paracrine modulators of brown adipose tissue mass and activity as novel therapeutic strategies against obesity and type 2 diabetes. Horm Mol Biol Clin Investig 2017; 29;31. [DOI:10.1515/hmbci-2017-0043]
46. Andersson DP, Laurencikiene J, Acosta JR, Rydén M, Arner P. Circulating and Adipose Levels of Adipokines Associated with Insulin Sensitivity in Nonobese Subjects with Type 2 Diabetes. J Clin Endocrinol Metab 2016;101:3765-3771. [DOI:10.1210/jc.2016-1883]
47. Yamauchi, T., Kamon, J., Waki, H. et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001;7:941-946. [DOI:10.1038/90984]
48. Ghaderpanahi M, Fakhrzadeh H, Sharifi F, Badamchizade Z, Mirarefin M, Ebrahim RP, et al. Association of physical activity with risk of type 2 diabetes. Iran J Public Health 2011;40:86-93.
49. Boutcher SH. High-intensity intermittent exercise and fat loss. J Obes 2011;2011:868305 [DOI:10.1155/2011/868305]
50. Simpson KA, Singh MA. Effects of exercise on adiponectin: a systematic review. Obesity (Silver Spring) 2008;16:241-56. [DOI:10.1038/oby.2007.53]
51. Francois ME, Little JP. Effectiveness and safety of high-intensity interval training in patients with type 2 diabetes. Diabetes Spectr 2015;28:39-44. [DOI:10.2337/diaspect.28.1.39]
52. Patel H, Alkhawam H, Madanieh R, Shah N, Kosmas CE, Vittorio TJ. Aerobic vs anaerobic exercise training effects on the cardiovascular system. World J Cardiol 2017;9:134-138. [DOI:10.4330/wjc.v9.i2.134]
53. Shing CM, Webb JJ, Driller MW, Williams AD, Fell JW. Circulating adiponectin concentration and body composition are altered in response to high-intensity interval training. J Strength Cond Res 2013 ;27:2213-8. [DOI:10.1519/JSC.0b013e31827e1644]
54. Lee SH, Hong HR, Han TK, Kang HS. Aerobic training increases the expression of adiponectin receptor genes in the peripheral blood mononuclear cells of young men. Biol Sport 2015;32:181-6. [DOI:10.5604/20831862.1150298]
55. Leggate M, Carter WG, Evans MJ, Vennard RA, Sribala-Sundaram S, Nimmo MA. Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males. J Appl Physiol 2012 ;112:1353-60. [DOI:10.1152/japplphysiol.01080.2011]
56. Choudhury H, Pandey M, Hua CK, Mun CS, Jing JK, Kong L, et al. An update on natural compounds in the remedy of diabetes mellitus: A systematic review. J Tradit Complement Med 2017;8:361-376. [DOI:10.1016/j.jtcme.2017.08.012]
57. Surjushe A, Vasani R, Saple DG. Aloe vera: a short review. Indian J Dermatol 2008;53:163-6. [DOI:10.4103/0019-5154.44785]
58. Alinejad-Mofrad S, Foadoddini M, Saadatjoo SA, Shayesteh M. Improvement of glucose and lipid profile status with Aloe vera in pre-diabetic subjects: a randomized controlled-trial. J Diabetes Metab Disord 2015; 14:22. [DOI:10.1186/s40200-015-0137-2]
59. Thomas C, Bishop D, Moore-Morris T, Mercier J. Effects of high-intensity training on MCT1, MCT4, and NBC expressions in rat skeletal muscles: influence of chronic metabolic alkalosis. Am J Physiol Endocrinol Metab 2007;293: E916-22. [DOI:10.1152/ajpendo.00164.2007]
60. Erfani MN, Bahrami M, Morovvati H, Najafzade H. Study the protective effect of Aloe Vera's on histological and histometric changes in testis of diabetic rats. Iran Veterinary J 2013; 9; 78-87. [In Persian]
61. Singh B, Saxena A. Surrogate markers of insulin resistance: A review. World J Diabetes 2010;1:36-47. [DOI:10.4239/wjd.v1.i2.36]
62. Rahman MM, Kwon HS, Kim MJ, Go HK, Oak MH, Kim DH. Melatonin supplementation plus exercise behavior ameliorate insulin resistance, hypertension and fatigue in a rat model of type 2 diabetes mellitus. Biomed Pharmacother 2017; 92:606-614. [DOI:10.1016/j.biopha.2017.05.035]
63. Huang H, Iida KT, Sone H, Yokoo T, Yamada N, Ajisaka R. The effect of exercise training on adiponectin receptor expression in KKAy obese/diabetic mice. J Endocrinol 2006;189:643-53. [DOI:10.1677/joe.1.06630]
64. Kraemer RR, Castracane VD. Exercise and humoral mediators of peripheral energy balance: ghrelin and adiponectin. Exp Biol Med (Maywood) 2007;232:184-94.
65. Fatouros IG, Tournis S, Leontsini D, Jamurtas AZ, Sxina M, Thomakos P, et al. Leptin and adiponectin responses in overweight inactive elderly following resistance training and detraining are intensity related. J Clin Endocrinol Metab 2005;90:5970-7. [DOI:10.1210/jc.2005-0261]
66. Kelly AS, Steinberger J, Olson TP, Dengel DR. In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children. Metabolism 2007;56:1005-9. [DOI:10.1016/j.metabol.2007.03.009]
67. Zarekar M, Saghebjoo M, Foadodini M, Hedayati M. Combined Effect of Aerobic Training and Pistacia Athlantica Extract on GLUT-4 Protein Expression and Muscle Glycogen in Diabetic Rats. Iran J Endocrin Metab 2014; 16:245-253. [In Persian]
68. Mohammadi R, Matin Homaee H, Azarbayjani M, Baesi, K. he Effect of 12-Week Resistance Training Cardiac Hypertrophy, Glucose Level, Insulin, and Insulin Resistance Index in STZ-Induced Diabetic Rats. Qom Univ Med Sci J 2017;11:38-45. [In Persian]
69. Friedenreich CM, Neilson HK, Woolcott CG, McTiernan A, Wang Q, Ballard-Barbash R, et al. Changes in insulin resistance indicators, IGFs, and adipokines in a year-long trial of aerobic exercise in postmenopausal women. Endocr Relat Cancer 2011;18:357-69. [DOI:10.1530/ERC-10-0303]
70. Stanford KI, Goodyear LJ. Exercise and type 2 diabetes: molecular mechanisms regulating glucose uptake in skeletal muscle. Adv Physiol Educ 2014;38:308-14. [DOI:10.1152/advan.00080.2014]
71. Martin LJ, Woo JG, Daniels SR, Goodman E, Dolan LM. The relationships of adiponectin with insulin and lipids are strengthened with increasing adiposity. J Clin Endocrinol Metab 2005;90:4255-9. [DOI:10.1210/jc.2005-0019]
72. Eizadi M, Ravasi A A, Soori R, Baesi K, Choubineh S. Effect of three months aerobic training on TCF7L2 expression in pancreatic tissue in type 2 diabetes rats induced by streptozotocin- nicotinamide. Feyz 2017; 21:1-8. [In Persian] [DOI:10.17795/ajmb-34014]
73. Salehi O R, Hoseini A. The Effects of Endurance Trainings on Serum BDNF and Insulin Levels in Streptozotocin-Induced Diabetic Rats. Shafayeh Khatam 2017; 5:52-61. [In Persian] [DOI:10.18869/acadpub.shefa.5.2.52]
74. Chahardoli M, Mahmoodi M, Hajizadeh M, Khoramdel Azad H, Khoshdel A, Mirzaei M. Effect of Aloe Vera Hydroalcoholic Extract on Blood Glucose, Serum Insulin and the Key Enzymes in Metabolic Pathways of Glycolysis and Gluconeogenesis in Hepatocytes of Type 1 Diabetic Rats. JRUMS 2015; 13:669-682.
75. Mahmudzadeh T, Saghebjoo M, Seghatol Eslami A, Hedayati M. Effect of aerobic training and pistacia atlantica extract consumption on pancreatic β-cells function in streptozotocin-induced diabetic rats. Iran J Diabet Metab 2014; 13. [In Persian]
76. Eizadi M, Bahboudi L, Zahedmanesh F, Afsharmand Z. Effect of Acute andChronic Exercise on Beta-Cell Function in Diabetic Patients. Knowledge & Health 2012;6: 15-19. [In Persian]
77. Wang C, Guan Y, Yang J. Cytokines in the Progression of Pancreatic β-Cell Dysfunction. Int J Endocrinol 2010; 2010:515136. [DOI:10.1155/2010/515136]
78. de Salles BF, Simão R, Fleck SJ, Dias I, Kraemer-Aguiar LG, Bouskela E. Effects of resistance training on cytokines. Int J Sports Med 2010;31:441-50. [DOI:10.1055/s-0030-1251994]
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Sabzparvar M, Riyahi Malayeri S, Divkan B. Effect of high-intensity interval training and Aloe vera consumption on serum adiponectin and beta cells function in diabetic male rats. MEDICAL SCIENCES 2021; 31 (3) :299-306
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فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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