[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
About the Journal
Editorial Board
Aims& Scopes
Journal News
Articles archive::
Current Issue
All Issues
For Authors::
Call for Papers
Submission Instruction
Submission Form
For Reviewers::
Reviewers Section
Registration::
Registration Information
Registration Form
Contact us::
Contact Information
Contact us
Site Facilities::
Site map
Search contents
FAQ
Top 10 contents
Inform to friends
Webmail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 31, Issue 3 (Fall 2021) ::
MEDICAL SCIENCES 2021, 31(3): 290-298 Back to browse issues page
Preparation and invitro evaluation of extend release tablets containing carbamazepine 200mg using HPMC 4000cps
Zahra Saeedinia1 , Mohammad Reza Awadi2 , Ramin Asgharian 3
1- MSc of Pharmaceutical Chemistry, Faculty of Medicinal Chemistry, Tehran Medical Sciences,Islamic Azad University, Tehran, Iran
2- Research Director at Hakim Pharmaceutical Company, Tehran, Iran
3- Assistant Professor, Industrial Pharmacy, Faculty of Pharmacy, Tehran Medical Sciences,Islamic Azad University, Tehran, Iran , ramin3205@gmail.com
Abstract:   (3744 Views)
Background: Today, extended-release drug systems are among the most important issues in the field of pharmacy and biotechnology because in these systems, drug consumption can be significantly reduced, and as a result, their side effects and poisoning. It reduces the accumulation of drugs in the body and thus increases the patient's acceptance. The aim of this study was to prepare and in-vitro evaluation of extended-release tablets containing carbamazepine 200 mg using hydrophilic base of hydroxy propyl methylcellulose (HPMC) 4000Cp.
Materials and methods: The tablets were produced by using wet granulation. By adding various fillers such as lactose, avisel and magnesium stearate, the flowability and press ability of the granules were increased and polyvinyl pyrrolidone was used to increase the adhesion between the granule particles. Also, studies on the hardness, erosion, the amount of active ingredient in the tablets, and the amount of in-vitro drug release were performed on the optimal formulation. The effect of hydrophilic base and its amount on drug release was investigated by factorial design method.
Results: According to the results of drug release studies, abc formulation (PMC: 20%, PVP: 5%, Mg-St: 5%) was selected as the best formulation for the preparation of extended-release carbamazepine tablets. This formula has a release pattern according to the range announced by the American Pharmacopoeia.
Conclusion: It seems that the abc formulation, considering the available possibilities, can be a good choice for replacement with fast-release carbamazepine due to its advantages such as less side effects and better effects. It seems that the abc formulation, considering the available possibilities, can be a suitable option for replacement with fast-release carbamazepine due to its advantages such as less side effects and better effects.
Keywords: Extended release, Carbamazepine, HPMC 4000cps, in-vitro studies.
Full-Text [PDF 318 kb]   (1691 Downloads)    
Semi-pilot: Experimental | Subject: Pharmacology
Received: 2020/11/7 | Accepted: 2021/02/27 | Published: 2021/09/1
References
1. Dalby MA. Antiepileptic and psychotropic effect of carbamazepine (Tegretol) in the treatment of psychornotor epilepsy. Epilepcia 1971;12: 325-334. [DOI:10.1111/j.1528-1157.1971.tb04380.x]
2. Meldrum BS, Porter RJ, Editors. Current problems in epilepsy: new anticonvulsant drugs. London: John Libbey; 1986.
3. Jain KK, Editor. Drug Delivery Systems. USA: Humana Press; 2008. [DOI:10.1007/978-1-59745-210-6]
4. Clara M, Strenn B, Kreuzinger N. Carbamazepine as a possible anthropogenic marker in the aquatic environment: Investigations on the behaviour of Carbamazepine in wastewater treatment and during groundwater infiltration. Water Res 2004;38: 947-954. [DOI:10.1016/j.watres.2003.10.058]
5. Schramm C, Gans O, Uhl M, Grath J, Scharf S, Zieritz I, et al, Editors. Carbamazepin Und Koffein‐Potenzielle Screeningparameter Fur Verunreingungen Des Grundwassers Durch Kommunales Abwasser. Wien: Umweltbundesamt; 2006.
6. Marino SE, Pakhomov SV, Han S, Anderson KL, Ding M, Eberly LE, et al. The effect of topiramate plasma concentration on linguistic behavior, verbal recall and working memory. Epilepsy Behav 2012;24:365-72. [DOI:10.1016/j.yebeh.2012.04.120]
7. Katzhendler I, Azoury R, Friedman M. Crystalline properties of carbamazepine in sustained release hydrophilic matrix tablets based on hydroxypropyl methylcellulose. J Control Release 1998;54:69-85. [DOI:10.1016/S0168-3659(98)00002-9]
8. Free patents online. Controlled release solid dosage Carbamazepine formulations - United States Patent 6572889. Avaiable from: https://patents.google.com/patent/US6572889B1/en.
9. Guneysel O, Onur O, Denizbasi A, Saritemur M. Carbamazepine overdose after exposure to simethicone: a case report. J Med Case Rep 2008;2:242. [DOI:10.1186/1752-1947-2-242]
10. Philip F. Builders 1 and Mathew I. Arhewoh2 Pharmaceutical applications of native starch in conventional drug delivery 68, 1-10 DOI 10.1002/star.201500337. September 2016 [DOI:10.1002/star.201500337]
11. Chein YW. Oral Drug delivery and delivery systems. In: Novel drug delivery systems. New York: Marcel Dekker Inc.; 2002.
12. Ali W, Badawi AA, Mahdy MA, El-Nahas HM. Formulation and Evaluation of Carbamazepine 200 mg Controlled Release Tablets Using Different HPMC Grades. J Pharm Res Int 2013;3:632-647. [DOI:10.9734/BJPR/2013/3923]
13. Ju R.T.C, Nixon P.R, Patel M.V, Tong D.M. Drug release from hydrophilic matrices. 2. Amathematical model based on the disentanglement concentration and the diffusion layer. J Pharm Sci 1995;84:1464-1477. [DOI:10.1002/jps.2600841214]
14. Nagar M. formulation and evaluation of carbamazepine extended release tablet by controlled erosion technologyinternational. J Pharm Sci 2012; 4:0975-1491.
15. Charulatha R, Rajan K. Design and Evaluation of Carbamazepine Controlled Release Drug Delivery System International. J PharmTech Res 2012;4: 0974-4304.
16. Goldensohn ES, Porter RJ, Schwartzkroin PA. The American Epilepsy Society: an historic perspective on 50 years of advances in research. Epilepsia 1997;38:124-50. [DOI:10.1111/j.1528-1157.1997.tb01088.x]
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Saeedinia Z, Awadi M R, Asgharian R. Preparation and invitro evaluation of extend release tablets containing carbamazepine 200mg using HPMC 4000cps. MEDICAL SCIENCES 2021; 31 (3) :290-298
URL: http://tmuj.iautmu.ac.ir/article-1-1804-en.html
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 31, Issue 3 (Fall 2021) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
Persian site map - English site map - Created in 0.05 seconds with 37 queries by YEKTAWEB 4660