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:: Volume 30, Issue 3 (Fall 2020) ::
MEDICAL SCIENCES 2020, 30(3): 313-319 Back to browse issues page
Prevalence and association of adverse pregnancy outcomes in pregnant women with abnormal levels of serum markers in the first trimester of pregnancy at Tehran Nasl-Omid Center in 2012-2016
Maryamsadat Mirazimi 1, Fataneh Zonoozi2 , Saiedreza Ghaffari3 , Vahide Kazemi Majdabadi4
1- Obstetrician and Gynecologist, Iran University of Medical Sciences, Tehran, Iran , Mymirazimi63@gmail.com
2- Assistant Professor, Obstetrician and gynecologist, Iran University of Medical Sciences, Tehran, Iran
3- Department of Genetics, Nasl-Omid Laboratory, Tehran, Iran
4- General Surgeon, Iran University of Medical Sciences, Tehran, Iran
Abstract:   (2160 Views)
Background: Due to the role of the markers of the first trimester of pregnancy in the adverse pregnancy outcomes and the inadequacy of studies conducted in Iran, in this study the frequency and relationship between adverse pregnancy outcomes in mothers with abnormal PAPP-A and free βHCG values were investigated.
Materials and methods: In this cross- sectional study, 501 pregnant women referred to Nasl-Omid Laboratory in Tehran between 2012 and 2016 were studied. Demographic data, medical history and serum values of PAPP-A and free ß-HCG of pregnant women were collected from their medical record or via telephone interview. Cut-off of the markers was considered as 0.4 MOM.
Results: A total of 501 pregnant women with a mean age of 29.14±24.4 years and a gestational age of 37.8±1.67 weeks were studied. 37.9% of pregnant women had abnormal levels of markers. In NT sonography report, subchorionic hematomas were reported in 17.2% of subjects. A significant relationship was found between maternal diabetes and hypertension and preterm delivery with PAPP-A (p<0.001 and p=0.02, respectively). There was also a significant relationship between subchorionic hematoma, preterm delivery and fetal death with free βHCG (p= 0.02, p=0.02 and p=0.009, respectively).
Conclusion: Diabetes, high blood pressure, and preterm labor are related to PAPP-A, and subchorionic hematoma, preterm labor, and fetal death are associated with free ß-HCG.
Keywords: Serum PAPP-A, Free Beta HCG, Pregnancy outcomes.
Full-Text [PDF 285 kb]   (1842 Downloads)    
Semi-pilot: Survey/Cross Sectional/Descriptive | Subject: Gynecology
Received: 2019/07/28 | Accepted: 2019/08/28 | Published: 2020/09/20
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Mirazimi M, Zonoozi F, Ghaffari S, Kazemi Majdabadi V. Prevalence and association of adverse pregnancy outcomes in pregnant women with abnormal levels of serum markers in the first trimester of pregnancy at Tehran Nasl-Omid Center in 2012-2016. MEDICAL SCIENCES 2020; 30 (3) :313-319
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Volume 30, Issue 3 (Fall 2020) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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