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:: Volume 30, Issue 4 ( winter 2020) ::
MEDICAL SCIENCES 2020, 30(4): 418-424 Back to browse issues page
Comparison of antidepressant effect of Melissa officinalis L. hydroalcoholic extract with fluoxetine in male mice
Shadi Hajrasouliha1, Shahrzad Khakpour 2
1- Department of Biology, Herbal pharmacology Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Department of Biology, Roudehen Branch, Islamic Azad University, Roudehen, Iran
2- Department of Physioloy, Herbal Pharmacology research center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran , shahrzad_khakpour@yahoo.com
Abstract:   (385 Views)
Background: Depression is a common psychological disorder and recent data confirm the increasing prevalence of this disease in the world. So far, antidepressant effects of many plants have been evaluated and some are accepted in the treatment of depression. The aim of the present study was to determine the antidepressant effect of Melissa Officinalis L. compared to fluoxetine.
Materials and methods: In the present study, the antidepressant effect of Melissa officinalis L. was studied and compared with fluoxetine in experimental groups of mice using FST (Forced Swimming Test), TST (Tail Suspension Test). Melissa officinalis L. extract with different doses of 600,800, and 1000 mg/kg was prescribed by gavage for 7 days. One way ANOVA was used to analyze data by SPSS software.
Results: Among the different doses, 600 mg/kg Melissa officinalis L. extract and fluoxetine had the same effect in the reduction of depression.
Conclusion: The antidepressant effect of Melissa officinalis L. extract is probably induced by the variation of monoamines release in central nervous system.
Keywords: Melissa officinalis, Depression, Mice, Fluoxetine
Full-Text [PDF 357 kb]   (248 Downloads)    
Semi-pilot: Experimental | Subject: Physiology
Received: 2019/10/15 | Accepted: 2020/02/15 | Published: 2020/12/20
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Hajrasouliha S, Khakpour S. Comparison of antidepressant effect of Melissa officinalis L. hydroalcoholic extract with fluoxetine in male mice. MEDICAL SCIENCES. 2020; 30 (4) :418-424
URL: http://tmuj.iautmu.ac.ir/article-1-1848-en.html


Volume 30, Issue 4 ( winter 2020) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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