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:: دوره 31، شماره 4 - ( زمستان 1400 ) ::
جلد 31 شماره 4 صفحات 424-413 برگشت به فهرست نسخه ها
تأثیر تمرین منظم ورزش همگانی بر عملکرد نوتروفیلی، سطوح میلوپراکسیداز و ظرفیت آنتی اکسیدانی مردان میانسال
رضا رحیمی مقدم1 ، علی رضا علمیه 2، محمد رضا فدائی چافی3
1- دانشجوی دکترای فیزیولوژی ورزشی، گروه تربیت بدنی، واحد رشت، دانشگاه آزاد اسلامی، رشت، ایران
2- دانشیار، گروه تربیت بدنی، واحد رشت، دانشگاه آزاد اسلامی، رشت، ایران ، elmieh@iaurasht.acir
3- استادیار، گروه تربیت بدنی، واحد رشت، دانشگاه آزاد اسلامی، رشت، ایران
چکیده:   (2145 مشاهده)
سابقه و هدف: تمرین ورزشی می­تواند موجب بروز التهاب و فعالیت نوتروفیل­ها شود. نوتروفیل­ها حاوی آنزیم میلوپراکسیداز هستند که عملکرد اصلی آن تولید گونه­های واکنش پذیر اکسیژن است. همچنین، فعالیت بدنی می­تواند باعث بهبود عملکرد ایمنی و فعالیت آنتی اکسیدانی شود. بنابراین هدف تحقیق حاضر، مطالعه فعالیت نوتروفیل­ها، تغییرات میلوپراکسیداز و ظرفیت تام آنتی اکسیدانی مردان میانسال سالم شرکت کننده در فعالیتهای ورزش همگانی و افراد بدون تمرین بود.
روش بررسی: بیست نفر آزمودنی تمرین کرده (سن 94/2 ± 85/53 سال، نمایه توده بدنی [BMI] 6/1 ± 47/25 کیلوگرم بر مترمربع) و 17 نفر بدون تمرین (سن 83/2 ± 17/54 سال، BMI 12/1 ± 83/27 کیلوگرم بر مترمربع) در این مطالعه شرکت کردند. آزمودنی­ها تست اصلاح شده بروس را به عنوان مدلی از تمرین فزاینده انجام دادند. نمونه­های خونی قبل، بلافاصله بعد و یک ساعت پس از پایان تست دریافت شدند. 
یافته­ها: تفاوت معنی­داری در مقادیر نوتروفیل­های گروه تمرین کرده مشاهده شد. گروه بدون تمرین افزایش معنی­دار میلوپراکسیداز را نسبت به گروه تمرین کرده تجریه کرد. هر دو گروه تفاوت معنی­داری در ظرفیت تام آنتی اکسیدانی داشتند و گروه تمرین کرده به طور معنی­داری از سطوح بالاتری از ظرفیت تام آنتی اکسیدانی برخوردار بود.
نتیجه­گیری: شرکت منظم در فعالیت­های ورزش همگانی می­تواند باعث بهبود عملکرد نوتروفیل­ها، کاهش میلوپراکسیداز و افزایش ظرفیت تام آنتی اکسیدانی مردان میانسال سالم شود و ممکن است به طور بالقوه سرعت زوال تدریجی سیستم ایمنی ناشی از افزایش سن را کند کند.
واژه‌های کلیدی: فعالیت ورزش همگانی، نوتروفیل، میلوپراکسیداز، ظرفیت تام آنتی اکسیدانی
متن کامل [PDF 406 kb]   (1236 دریافت)    
نيمه آزمايشي : كارآزمايي باليني | موضوع مقاله: فيزيولوژي
دریافت: 1399/11/28 | پذیرش: 1400/2/19
فهرست منابع
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76. Ren M, Zhou K, He L, Lin W. Mitochondria and lysosome-targetable fluorescent probes for HOCl: recent advances and perspectives. J Mater Chem B 2018;6:1716-1733. [DOI:10.1039/C7TB03337K]
77. Khan AA, Alsahli MA, Rahmani AH. Myeloperoxidase as an Active Disease Biomarker: Recent Biochemical and Pathological Perspectives. Med Sci (Basel) 2018;6:33. [DOI:10.3390/medsci6020033]
78. Groussard C, Maillard F, Vazeille E, Barnich N, Sirvent P, Otero YF, et al. Tissue-Specific Oxidative Stress Modulation by Exercise: A Comparison between MICT and HIIT in an Obese Rat Model. Oxid Med Cell Longev 2019;2019:1965364. [DOI:10.1155/2019/1965364]
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Rahimi Moghaddam S R, Elmieh A, Fadaei Chafy M R. The effect of leisure time regular exercise on neutrophil function, myeloperoxidase levels, and antioxidant capacity in middle-aged men. MEDICAL SCIENCES 2021; 31 (4) :413-424
URL: http://tmuj.iautmu.ac.ir/article-1-1853-fa.html

رحیمی مقدم رضا، علمیه علی رضا، فدائی چافی محمد رضا. تأثیر تمرین منظم ورزش همگانی بر عملکرد نوتروفیلی، سطوح میلوپراکسیداز و ظرفیت آنتی اکسیدانی مردان میانسال. فصلنامه علوم پزشکی دانشگاه آزاد اسلامی تهران. 1400; 31 (4) :413-424

URL: http://tmuj.iautmu.ac.ir/article-1-1853-fa.html



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