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:: Volume 19, Issue 2 (Summer 2009) ::
MEDICAL SCIENCES 2009, 19(2): 105-109 Back to browse issues page
Comparative study of topiramate versus sodium valproate in the prevention of migraine headaches
Helen Fazlalizadeh 1, Fatemeh Khamseh , Behdad Soleimani , Ali Tajik
1- , helana_faz@yahoo.com
Abstract:   (23588 Views)
Background: Migraine prevention is a major step in control and decreasing frequency of this severe and disabling type of headache. Current study was performed to determine the comparative efficacy of topiramate and sodium valproate in the management of migraine headache.
Materials and methods: In this double-blind randomized clinical trial, among patients attending to Amir-al-momenin hospital between 2006 and 2007, 285 patients (50.1%) received sodium valproate with a dose of 200 mg/day and 284 subjects (49.9%) received topiramate with a dose of 100 mg/day for one month.
Results: 262 patients (91.9%) in sodium valproate group and 266 subjects (93.7%) in topiramate group had good response to treatment (NS). In sodium valproate group, 40 patients (14%) and in topiramate group, 41 subjects (14.4%) experienced drug adverse effects (NS).
Conclusion: According to lack of statistically significant differences between therapeutic efficacy and adverse effects of sodium valproate and topiramate, both modalities may be indicated upon with patient's conditions and physician's opinion.
Keywords: Migraine, Sodium Valproate, Topiramate
Full-Text [PDF 131 kb]   (2885 Downloads)    
Subject: Epidemiology
Received: 2006/09/6 | Published: 2009/07/15
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Fazlalizadeh H, Khamseh F, Soleimani B, Tajik A. Comparative study of topiramate versus sodium valproate in the prevention of migraine headaches. MEDICAL SCIENCES 2009; 19 (2) :105-109
URL: http://tmuj.iautmu.ac.ir/article-1-198-en.html


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Volume 19, Issue 2 (Summer 2009) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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