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:: Volume 33, Issue 1 (spring 2023) ::
MEDICAL SCIENCES 2023, 33(1): 21-28 Back to browse issues page
Effects of Phoenix dactylifera extract and testosterone enanthate with and without resistance training on MFN2, FISS and DRP1 genes expression in liver of rat
Zahra Alikaei1 , Mohammad Ali Azarbayjani 2, Sirvan Atashak3 , Maghsoud Peeri1 , Saleh Rahmati-Ahmadabad4
1- Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
2- Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran , m_azarbayjani@iauctb.ac.ir
3- Department of Physical Education, Mahabad Branch, Islamic Azad University, Mahabad, Iran
4- Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Iran
Abstract:   (868 Views)
Background: The use of testosterone enanthate has increased among athletes, especially in resistance disciplines. Considering the side effects of using testosterone enanthate, it seems necessary to find alternative methods. The present study compared the independent and interactive effects of resistance training, testosterone and palm pollen extract on mRNA expression of MFN2, FISS and DRP1 genes in male rat liver.
Materials and methods: In a experimental study, 30 male rats were divided into control groups, resistance training, date pollen extract, testosterone ethanate, consumption of date pollen extract + resistance training and testosterone etantate + resistance training. The interventions were applied based on the group name for four weeks. 48 hours after the last intervention, the liver tissue was investigated to measure the expression of MFN2, FISS and DRP1 genes.
Results: Exercise, testosterone and date pollen, each independently, increased the expression of MFN2 gene and decreased the expression of FISS and DRP1 genes in the liver. The simultaneous use of exercise and testosterone/palm pollen strengthened the effect of independent interventions; however, the synergistic effect was observed only on liver FISS gene expression compared to independent interventions.
Conclusion: According to the results of the groups consuming date pollen and testosterone, it seems that the use of each of them has caused a similar pattern of change in the variables of the present study; therefore, the use of date pollen may be a natural alternative to testosterone.
Keywords: Resistance training, Liver, Testosterone, Palm pollen extract, Gene expression
Full-Text [PDF 365 kb]   (442 Downloads)    
Semi-pilot: Experimental | Subject: Physiology
Received: 2022/07/8 | Accepted: 2022/10/11 | Published: 2023/03/30
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Alikaei Z, Azarbayjani M A, Atashak S, Peeri M, Rahmati-Ahmadabad S. Effects of Phoenix dactylifera extract and testosterone enanthate with and without resistance training on MFN2, FISS and DRP1 genes expression in liver of rat. MEDICAL SCIENCES 2023; 33 (1) :21-28
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Volume 33, Issue 1 (spring 2023) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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