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Evaluation of the effects of psyllium polymer on the release behavior of diclofenac sodium from extended-release matrix tablets
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Ehsan Beiranvand1    , Seyed Alireza Mortazavi2 , Seyedeh Maryam Ortazavi3 |
1- Department of Pharmaceutics, TMS, Islamic Azad University, Tehran, Iran
2- Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran , mmortazavi@sbmu.ac.ir |
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Abstract: (8 Views) |
Abstract
Background: Extended-release tablets offer several advantages, including reduced dosing frequency, maintaining relatively constant plasma concentrations, and minimizing dose-dependent side effects. These tablets can be formulated as matrix systems using hydrophilic polymers. Psyllium, as a natural polymer, is gaining attention for being safe, cost-effective, readily available, and biocompatible. The aim of this study was to develop extended-release diclofenac sodium tablets using a hydrophilic matrix of psyllium combined with HPMC 15000 cps.
Materials and methods: The tablets were prepared using two methods: direct compression and wet granulation. Psyllium and HPMC 15000 cps were used as retardants, microcrystalline cellulose as a filler, and magnesium stearate or sodium lauryl sulfate (SLS) as lubricants. Finally, the formulations were evaluated for thickness, hardness, friability, assay, swelling, release, and release kinetics.
Results: The formulations prepared using the wet granulation method passed the physical tests. Based on the drug release and release kinetics tests, formulations B7 and B8 met the USP monograph criteria for release rates at specified time intervals. Additionally, the release kinetics for both formulations followed the Korsmeyer-Peppas model. The optimized formulations reached maximum swelling after approximately 4 hours.
Conclusion: Based on the data, it can be concluded that formulations B7 and B8 represent optimized diclofenac formulations using psyllium as a matrix.
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| Keywords: Matrix tablets, Extended release, Release behavior, Diclofenac sodium, Natural polymer psyllium. |
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Full-Text [PDF 1057 kb]
(1 Downloads)
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Semi-pilot: Experimental |
Subject:
Pharmacology
Received: 2024/10/31 | Accepted: 2025/03/17 | Published: 2025/12/1
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