[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
About the Journal
Editorial Board
Aims& Scopes
Journal News
Articles archive::
Current Issue
All Issues
Browse by Authors
Browse by Keywords
For Authors::
Call for Papers
Submission Instruction
Submission Form
For Reviewers::
Reviewers Section
Registration::
Registration Information
Registration Form
Contact us::
Contact Information
Contact us
Site Facilities::
Site map
Search contents
FAQ
Top 10 contents
Inform to friends
Webmail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 35, Issue 4 (winter 2025) ::
MEDICAL SCIENCES 2025, 35(4): 415-425 Back to browse issues page
Evaluation of the effects of psyllium polymer on the release behavior of diclofenac sodium from extended-release matrix tablets
Ehsan Beiranvand1 , Seyed Alireza Mortazavi2 , Seyedeh Maryam Mortazavi3
1- Department of Pharmaceutics, TMS, Islamic Azad University, Tehran, Iran
2- Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran , mmortazavi@sbmu.ac.ir
Abstract:   (296 Views)
Abstract

Background: Extended-release tablets offer several advantages, including reduced dosing frequency, maintaining relatively constant plasma concentrations, and minimizing dose-dependent side effects. These tablets can be formulated as matrix systems using hydrophilic polymers. Psyllium, as a natural polymer, is gaining attention for being safe, cost-effective, readily available, and biocompatible. The aim of this study was to develop extended-release diclofenac sodium tablets using a hydrophilic matrix of psyllium combined with HPMC 15000 cps.
Materials and methods: The tablets were prepared using two methods: direct compression and wet granulation. Psyllium and HPMC 15000 cps were used as retardants, microcrystalline cellulose as a filler, and magnesium stearate or sodium lauryl sulfate (SLS) as lubricants. Finally, the formulations were evaluated for thickness, hardness, friability, assay, swelling, release, and release kinetics.
Results: The formulations prepared using the wet granulation method passed the physical tests. Based on the drug release and release kinetics tests, formulations B7 and B8 met the USP monograph criteria for release rates at specified time intervals. Additionally, the release kinetics for both formulations followed the Korsmeyer-Peppas model. The optimized formulations reached maximum swelling after approximately 4 hours.
Conclusion: Based on the data, it can be concluded that formulations B7 and B8 represent optimized diclofenac formulations using psyllium as a matrix.
 
Keywords: Matrix tablets, Extended release, Release behavior, Diclofenac sodium, Natural polymer psyllium.
Full-Text [PDF 1057 kb]   (121 Downloads)    
Semi-pilot: Experimental | Subject: Pharmacology
Received: 2024/10/31 | Accepted: 2025/03/17 | Published: 2025/12/1
References
1. Raja SN, Carr DB, Cohen M, Finnerup NB, Flor H, Gibson S, et al. The revised IASP definition of pain: Concepts, challenges, and compromises. Pain 2020;161:1976. [DOI:10.1097/j.pain.0000000000001939]
2. Katz N. The impact of pain management on quality of life. J Pain Symptom Manage 2002;24:S38-47. [DOI:10.1016/S0885-3924(02)00411-6]
3. Savaşer A, Özkan Y, Işımer A. Preparation and in vitro evaluation of sustained release tablet formulations of diclofenac sodium. Farmaco 2005;60:171-7. [DOI:10.1016/j.farmac.2004.10.001]
4. Kaialy W, Emami P, Asare-Addo K, Shojaee S, Nokhodchi A. Psyllium: a promising polymer for sustained release formulations in combination with HPMC polymers. Pharm Dev Technol 2014;19:269-77. [DOI:10.3109/10837450.2013.775156]
5. Singh B. Psyllium as therapeutic and drug delivery agent. Int J Pharm 2007;334:1-14. [DOI:10.1016/j.ijpharm.2007.01.028]
6. Preidis GA, Chumpitazi BP, Shulman RJ. The microbiome in neurogastroenterology. In: Faure C, Thapar N, Di Lorenzo C, eds. Pediatric Neurogastroenterology: Gastrointestinal Motility Disorders and Disorders of Gut-Brain Interaction in Children. New York: Springer; 2023. p. 73-93. [DOI:10.1007/978-3-031-15229-0_6]
7. Thakur VK, Thakur MK. Recent trends in hydrogels based on psyllium polysaccharide: A review. J Clean Prod 2014;82:1-15. [DOI:10.1016/j.jclepro.2014.06.066]
8. Oliver SD. The long-term safety and tolerability of ispaghula husk. J R Soc Promot Health 2000;120:107-11. [DOI:10.1177/146642400012000208]
9. Siahi-Shadbad MR, Asare-Addo K, Azizian K, Hassanzadeh D, Nokhodchi A. Release behaviour of propranolol HCl from hydrophilic matrix tablets containing psyllium powder in combination with hydrophilic polymers. AAPS PharmSciTech 2011;12:1176-82. [DOI:10.1208/s12249-011-9687-x]
10. Ganesh GNK, Sureshkumar R, Jawahar N, Senthil V, Nagasamy Venkatesh D, Shanmukha Srinivas M. Preparation and evaluation of sustained release matrix tablet of diclofenac sodium using natural polymer. Journal of Pharmaceutical Sciences and Research 2010;2:360-68.
11. Yeole, P., et al., Design and evaluation of xanthan gum-based sustained release matrix tablets of diclofenac sodium. Indian Journal of Pharmaceutical Sciences, 2006. 68(2). [DOI:10.4103/0250-474X.25712]
12. Rowe RC, Sheskey PJ, Quinn ME, eds. Handbook of pharmaceutical excipients. 6th ed. London: Pharmaceutical Press; 2009.
13. Mortazavi SM, Mortazavi SA. Propranolol Hydrochloride Buccoadhesive Tablet: Development and In-vitro Evaluation. Iran J Pharm Res 2020;19:22-33.
14. Costa P, Lobo JMS. Modeling and comparison of dissolution profiles. Eur J Pharm Sci 2001;13:123-33. [DOI:10.1016/S0928-0987(01)00095-1]
15. Higuchi T. Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci 1963;52:1145-9. [DOI:10.1002/jps.2600521210]
16. Dash S, Murthy PN, Nath L, Chowdhury P. Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol Pharm 2010;67:217-23.
17. Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. Mechanisms of solute release from porous hydrophilic polymers. Int J Pharm 1983;15:25-35. [DOI:10.1016/0378-5173(83)90064-9]
18. Taylor KMG, Aulton ME, eds. Aulton's Pharmaceutics: The Design and Manufacture of Medicines. Vol. 1. 5th ed. London: Elsevier Health Sciences; 2021. 946 p.
19. Sinko PJ, ed. Martin's Physical Pharmacy and Pharmaceutical Sciences. 7th ed. Philadelphia: Wolters Kluwer Health; 2023.
20. Dun J, Zhang W, Zhang Y, et al. A systematic evaluation of dual functionality of sodium lauryl sulfate as a tablet lubricant and wetting enhancer. Int J Pharm 2018;552:139-47. [DOI:10.1016/j.ijpharm.2018.09.056]
21. Zeng A, Zhang L, Zhang Y, et al. Influence of sodium dodecyl sulfate on swelling, erosion and release behavior of HPMC matrix tablets containing a poorly water-soluble drug. Pharm Dev Technol 2009;14:499-505. [DOI:10.1080/10837450902773592]
22. Kumar R, Sharma K. Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems. Front Chem Sci Eng 2013;7:116-22. [DOI:10.1007/s11705-013-1310-0]
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Beiranvand E, Mortazavi S A, Mortazavi S M. Evaluation of the effects of psyllium polymer on the release behavior of diclofenac sodium from extended-release matrix tablets. MEDICAL SCIENCES 2025; 35 (4) :415-425
URL: http://tmuj.iautmu.ac.ir/article-1-2325-en.html
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 35, Issue 4 (winter 2025) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
Persian site map - English site map - Created in 0.03 seconds with 37 queries by YEKTAWEB 4732