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:: Volume 35, Issue 4 (winter 2025) ::
MEDICAL SCIENCES 2025, 35(4): 461-469 Back to browse issues page
The study of correlation of Selenium serum level with thyroid disorders in patients with end-stage renal disease in dialysis departments of Buali and Farhikhtegan Hospitals in 2022-2023
Sepinood Nematollahi Sani1 , Farahnaz Pasha2 , Laleh Ghanei3
1- Internal Medicine Specialist, TeMS.C. Islamic Azad University, Tehran, Iran
2- Assistant Professor of Internal Medicine, Nephrology Subspecialty, Farhikhtegan Hospital, TeMS.C. Islamic Azad University, Tehran, Iran , farahnazpasha@gmail.com
3- Assistant Professor of Internal Medicine, Endocrinology and Metabolism Subspecialty, Farhikhtegan Hospital, TeMS.C. Islamic Azad University, Tehran, Iran
Abstract:   (297 Views)
Abstract

Background: Selenium, a trace element, plays a crucial role in thyroid function and has been linked to various thyroid disorders. Patients with end-stage renal disease (ESRD) undergoing hemodialysis often experience disruptions in both selenium levels and thyroid function. This study aimed to evaluate the correlation between selenium serum levels and thyroid disorders in ESRD patients.
Materials and methods: This case-control study was conducted on 62 ESRD patients undergoing hemodialysis at Buali and Farhikhtegan Hospitals between 2022 and 2023. Patients were divided into two groups: those with thyroid disorders (hypothyroidism or hyperthyroidism) and those without. Data on serum selenium, TSH, T3, T4, triglycerides (TG), and albumin (Alb) were collected through medical records and laboratory tests. Statistical analysis was performed using ANOVA and Pearson correlation.
Results: The mean serum selenium level was 86.30 µg/L in the case group and 86.17 µg/L in the control group, with no significant difference between the groups (p=0.988). The mean TG level in the case group was 161.90 mg/dL and 129.00 mg/dL in the control group, with no significant difference (p=0.304). Similarly, no significant difference in Alb levels was observed between the case group (3.99 g/dL) and the control group (3.99 g/dL) (p=0.975). There was no meaningful relationship between decreased selenium levels and TSH, T3, T4, TG, or Alb levels.
Conclusion: This study suggests that while selenium is essential for thyroid function, reduced selenium levels do not significantly influence thyroid hormones, TG, or Alb levels in CKD patients undergoing hemodialysis.
 
Keywords: Selenium, Thyroid disorders, TSH, T3, T4, Hemodialysis, End-stage renal disease (ESRD).
Full-Text [PDF 889 kb]   (99 Downloads)    
Semi-pilot: Case Report | Subject: Nephrology
Received: 2024/10/30 | Accepted: 2025/02/16 | Published: 2025/12/1
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Nematollahi Sani S, Pasha F, Ghanei L. The study of correlation of Selenium serum level with thyroid disorders in patients with end-stage renal disease in dialysis departments of Buali and Farhikhtegan Hospitals in 2022-2023. MEDICAL SCIENCES 2025; 35 (4) :461-469
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Volume 35, Issue 4 (winter 2025) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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