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:: Volume 35, Issue 3 (Fall 2025) ::
MEDICAL SCIENCES 2025, 35(3): 377-381 Back to browse issues page
A rare case of corneal ulcer caused by pythium insidiosum diagnosed with PCR screening and DNA sequencing: a case report
Mehran Zarei-Ghanavati1 , Mehrnaz Atighehchian2 , Zakieh Vahedian2 , Fatemeh Bazvand2 , Seyed Mehdi Tabatabaei2 , Esmaeil Asadi Khameneh12
1- Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran , mehran_zarei@yahoo.com
2- Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (253 Views)
This report discusses a case involving infectious corneal ulcers in a 32-year-old pregnant woman. The clinical presentation of keratitis did not align with the typical signs of fungal keratitis. Initial investigations, including corneal scraping for smear and culture samples, showed no evidence of fungal infection, leading to the start of topical antibacterial treatment. Despite this, there was still a concern about a fungal infection, which led to repeat sampling. Unfortunately, the patient's condition progressed, even after the application of topical antifungal medications. This progression resulted in an intraocular infection known as endophthalmitis. Due to the inability to manage the infection effectively, the affected eye was ultimately eviscerated. Further evaluation, including advanced diagnostic techniques like polymerase chain reaction, showed that the cause of the infection was a rare quasi-fungal organism called Pythium insidiosum
Keywords: Keratitis, Corneal ulcer, Polymerase chain reaction, Pythium insidiosum.
Full-Text [PDF 910 kb]   (103 Downloads)    
Semi-pilot: Case Report | Subject: Ophtalmology
Received: 2024/12/30 | Accepted: 2025/03/12 | Published: 2025/09/1
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Zarei-Ghanavati M, Atighehchian M, Vahedian Z, Bazvand F, Tabatabaei S M, Asadi Khameneh1 E. A rare case of corneal ulcer caused by pythium insidiosum diagnosed with PCR screening and DNA sequencing: a case report. MEDICAL SCIENCES 2025; 35 (3) :377-381
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Volume 35, Issue 3 (Fall 2025) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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