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The role of exosomes in bone tissue regeneration: signaling mechanisms and therapeutic potential – a mini review
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Morteza Nakhaei Amroodi1    , Pouria Tabrizian1 , Mohammadreza Bahaeddini1 , Tohid Emami Meybodi2 , Khatere Mokhtari3 , Alireza Askari4 |
1- MD, Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Department of Orthopedic, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
2- Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran - Functional Neurosurgery Research Center, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran
4- MD, Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Department of Orthopedic, School of Medicine, Iran University of Medical Sciences, Tehran, Iran , aaskari60@yahoo.com |
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Abstract: (7 Views) |
| Bone tissue regeneration is a complex process primarily regulated through cell-cell interactions, cell-matrix communications, and paracrine signaling. Exosomes, extracellular vesicles of endocytic origin, play a crucial role in bone regeneration due to their unique cargo, which includes proteins and microRNAs. These vesicles actively regulate key cellular processes such as differentiation, migration, and apoptosis of bone cells. This review explores the role of exosomes in bone homeostasis, intercellular communication, and their therapeutic potential in enhancing bone regeneration |
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| Keywords: Exosomes, Bone tissue regeneration, Paracrine signaling, Osteoblasts, Osteocytes, Bone homeostasis. |
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Full-Text [PDF 739 kb]
(3 Downloads)
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Semi-pilot: Review |
Subject:
Molecular Biology
Received: 2025/03/9 | Accepted: 2025/05/12 | Published: 2025/12/1
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