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:: Volume 36, Issue 2 (summer 2026) ::
MEDICAL SCIENCES 2026, 36(2): 247-253 Back to browse issues page
Study of the relationship between cobalamin deficiency in patients with RUT-positive Helicobacter pylori infection who visited hospitals of Tehran Islamic Azad University of Medical Sciences
Farzaneh Tarkhoni1 , Somayeh Khamsi2 , Mehdi Afkar3
1- Internal Medicine Assistant Student, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2- Assistant Professor, Department of Internal Medicine, Oncology Subspecialist, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran , beyasin12@gmail.com
3- Assistant Professor of Community Medicine, Faculty of Medicine, Tehran Medical Sciences Islamic Azad University, Tehran, Iran
Abstract:   (340 Views)
Background: Helicobacter pylori infection is one of the major causes of gastrointestinal disorders. This study aimed to investigate the frequency of cobalamin deficiency in patients with Helicobacter pylori infection diagnosed by rapid urease test (RUT).
Materials and methods: A descriptive cross-sectional study was conducted at hospitals affiliated with Islamic Azad University of Medical Sciences in Tehran between 2023 and 2025. A total of 105 patients with Helicobacter pylori infection confirmed by the RUT method were included. Blood samples were collected from all participants to assess vitamin B12 levels. Statistical analysis was performed using SPSS software, with descriptive statistics and Chi-square and T-Test to analyze the data.
Results: Of 105 patients, 32 (30.5%) had cobalamin deficiency and 73 (69.5%) did not have cobalamin deficiency. 78.1% of patients had abdominal pain, 49.5% had nausea and vomiting, and 54.3% had gastric ulcers. A significant relationship was observed between gender, abdominal pain, nausea, gastric ulcers, or cobalamin deficiency (P< 0.05).
Conclusion: This study showed that the prevalence of cobalamin deficiency is high in patients with Helicobacter pylori infection. These findings highlight the importance of assessing cobalamin levels in patients with Helicobacter pylori infection for better management and prevention of potential deficiencies
Keywords: Helicobacter pylori, vitamin B12 deficiency, Rapid Urease Test (RUT).
Full-Text [PDF 541 kb]   (78 Downloads)    
Semi-pilot: Survey/Cross Sectional/Descriptive | Subject: Gastrology
Received: 2025/05/6 | Accepted: 2025/08/25 | Published: 2026/07/1
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Tarkhoni F, Khamsi S, Afkar M. Study of the relationship between cobalamin deficiency in patients with RUT-positive Helicobacter pylori infection who visited hospitals of Tehran Islamic Azad University of Medical Sciences. MEDICAL SCIENCES 2026; 36 (2) :247-253
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Volume 36, Issue 2 (summer 2026) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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