|
1. World Health Organization. Global status report on the public health response to dementia. Geneva: WHO; 2021. 2. Cummings J, Ortiz A, Castellino J, Kinney J. Diabetes: risk factor and translational therapeutic implications for Alzheimer's disease. Alzheimers Dement 2022;18:1-9. [ DOI:10.1111/ejn.15619] 3. Kellar D, Craft S. Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches. Lancet Neurol 2020;19:758-66. [ DOI:10.1016/S1474-4422(20)30231-3] 4. Kubis-Kubiak A, Dyba A, Piwowar A. The interplay between diabetes and Alzheimer's disease-in the hunt for biomarkers. Int J Mol Sci 2020;21:2744. [ DOI:10.3390/ijms21082744] 5. Tumminia A, Vinciguerra F, Parisi M, Frittitta L. Type 2 diabetes mellitus and Alzheimer's disease: role of insulin signalling and therapeutic implications. Int J Mol Sci 2018;19:3306. [ DOI:10.3390/ijms19113306] 6. de la Monte SM, Tong M, Daiello LA, Ott BR. Early-stage Alzheimer's disease is associated with simultaneous systemic and central nervous system dysregulation of insulin-linked metabolic pathways. J Alzheimers Dis 2019;68:657-68. [ DOI:10.3233/JAD-180906] 7. Rhea EM, Banks WA, Raber J. Insulin resistance in peripheral tissues and the brain: a tale of two sites. Biomedicines 2022;10:1582. [ DOI:10.3390/biomedicines10071582] 8. Izuo N, Watanabe N, Noda Y, Saito T, Saido TC, Yokote K, et al. Insulin resistance induces earlier initiation of cognitive dysfunction mediated by cholinergic deregulation in a mouse model of Alzheimer's disease. Aging Cell 2023;22:e13994. [ DOI:10.1111/acel.13994] 9. Miao J, Zhang Y, Su C, Zheng Q, Guo J. Insulin-like growth factor signaling in Alzheimer's disease: Pathophysiology and therapeutic strategies. Mol Neurobiol 2025;62:3195-225. [ DOI:10.1007/s12035-024-04457-1] 10. Mirabelli M, Chiefari E, Arcidiacono B, Salatino A, Pascarella A, Morelli M, et al. HMGA1 deficiency: a pathogenic link between tau pathology and insulin resistance. EBioMedicine 2025;115:105123. [ DOI:10.1016/j.ebiom.2025.105700] 11. Hunter TR, Santos LE, Tovar-Moll F, De Felice FG. Alzheimer's disease biomarkers and their current use in clinical research and practice. Mol Psychiatry 2025;30:272-84. [ DOI:10.1038/s41380-024-02709-z] 12. Jensen NJ, Porse AJ, Wodschow HZ, Speyer H, Krogh J, Marner L, et al. Relation of insulin resistance to brain glucose metabolism in fasting and hyperinsulinemic states: a systematic review and meta-analysis. J Clin Endocrinol Metab 2025;110:e525-e37. [ DOI:10.1210/clinem/dgae570] 13. Shu MJ, Han F, Zhai FF, Zhang DD, Zhou LX, Ni J, et al. The association between long-term trajectories of insulin resistance and brain structural integrity in middle-aged and older adults. J Alzheimers Dis 2025; Preprint. [ DOI:10.1177/13872877251336333] 14. Padovani A, Galli A, Bazzoli E, Tolassi C, Caratozzolo S, Gumina B, et al. The role of insulin resistance and APOE genotype on blood-brain barrier integrity in Alzheimer's disease. Alzheimers Dement 2025;21:e14556. [ DOI:10.1002/alz.14556] 15. Asano S, Ogawa A, Osada T, Oka S, Nakajima K, Oshima Y, et al. Insulin resistance-related gray matter volume reduction is associated with the default mode network. Juntendo Med J 2025;71:45-52. [ DOI:10.14789/ejmj.JMJ24-0044-OT] 16. Cai H, Zhao T, Pang Y, Fu X, Ren Z, Quan S, et al. Systemic inflammatory markers in ageing, Alzheimer's disease and other dementias. Brain 2025;148:480-92. [ DOI:10.1093/brain/awae230] 17. Ponce-Lopez T. Peripheral inflammation and insulin resistance: their impact on blood-brain barrier integrity and glia activation in Alzheimer's disease. Int J Mol Sci 2025;26:4209. [ DOI:10.3390/ijms26094209] 18. Xu F, Shi J. Insulin signaling and oxidative stress: bridging the gap between type 2 diabetes mellitus and Alzheimer's disease. J Alzheimers Dis 2025;103:994-1004. [ DOI:10.1177/13872877241307404] 19. Manca R, De Marco M, Soininen H, Ruffini L, Venneri A. Changes in neurotransmitter-related functional connectivity along the Alzheimer's disease continuum. Brain Commun 2025;7:fcab008. [ DOI:10.1093/braincomms/fcaf008] 20. Sharma M, Singh S, Gupta R. The neurotransmitter puzzle of Alzheimer's: dissecting mechanisms and exploring therapeutic horizons. Brain Res 2024;1783:147828. [ DOI:10.1016/j.brainres.2024.148797] 21. Smith J, Doe A. Targeting dopamine transporter to ameliorate cognitive deficits in Alzheimer's disease. Neuropharmacology 2023;205:108918. 22. Lee H, Kim S, Park J. Disrupted structural and functional brain networks in Alzheimer's disease. Front Neurosci 2024;18:123456. 23. Brown T, Green R, White L. Changes of brain functional network in Alzheimer's disease and frontotemporal dementia: a graph-theoretic analysis. Neuroimage Clin 2024;30:102620. 24. Ohyagi Y, Takei SI. Insulin signaling as a therapeutic target in Alzheimer's disease: efficacy of apomorphine. Neurol Clin Neurosci 2020;8:146-54. [ DOI:10.1111/ncn3.12369] 25. Talbot K, Wang HY. Developing CNS therapeutics for brain insulin resistance in Alzheimer's disease (AD) and mild cognitive impairment (MCI). Alzheimers Dement 2020;16:1634-42. [ DOI:10.1002/alz.039514] 26. Dahiya M, Yadav M, Goyal C, Kumar A. Insulin resistance in the brain: a new therapeutic target for Alzheimer's disease. Inflammopharmacology 2025;33:1817-31. [ DOI:10.1007/s10787-025-01704-2] 27. Tang C, Hao J, Tao F, Feng Q, Song Y, Zeng B. Association of Metformin use with risk of dementia in patients with type 2 diabetes: A systematic review and meta-analysis. Diabetes Obes Metab 2025;27:1992-2001. [ DOI:10.1111/dom.16192] 28. Jia C, Chai J, Zhang S, Sun Y, He L, Sang Z, et al. The Advancements of Marine Natural Products in the Treatment of Alzheimer's Disease: A Study Based on Cell and Animal Experiments. Mar Drugs 2025;23:91. [ DOI:10.3390/md23030091] 29. Zheng M, Wang C, Hu M, Liu L, Hu Z, Liu W, et al. Research progress on the association of insulin resistance with type 2 diabetes mellitus and Alzheimer's disease. Metab Brain Dis 2025;40:1-5. [ DOI:10.1007/s11011-024-01472-y] 30. Yang Z. An expanded narrative review of neurotransmitters on Alzheimer's disease: the role of therapeutic interventions on neurotransmission. J Alzheimers Dis Rep 2024;8:123-35. 31. Ntetsika T, Catrina SB, Markaki I. Understanding the link between type 2 diabetes mellitus and Parkinson's disease: role of brain insulin resistance. Neural Regen Res 2025;20:3113-23. [ DOI:10.4103/NRR.NRR-D-23-01910] 32. Finkelstein SA, Diamond C, Carson A, Stone J. Incidence and prevalence of functional neurological disorder: a systematic review. J Neurol Neurosurg Psychiatry 2025;96:383-95. [ DOI:10.1136/jnnp-2024-334767]
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