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:: Volume 21, Issue 2 (summer 2011) ::
MEDICAL SCIENCES 2011, 21(2): 97-100 Back to browse issues page
Role of fibrocytes (CD34+) derived from peripheral blood in the pathology of dermal fibrosis in a model of scleroderma
Majid Katebi1 , Zahra Nadia Sharifi2 , Shabnam Movassaghi2 , Hamid Reza Chegini2 , Simin Fazelipoor2 , Mohammad Ali Abbasi Moghadam2 , Mansooreh Soleimani 3
1- Hormozgan University of Medical Sciences, Bandar Abbas, Iran
2- Tehran Medical Branch, Islamic Azad University, Tehran, Iran
3- Tehran University of Medical Sciences, Tehran, Iran , mansourehsoleimani@gmail.com
Abstract:   (23613 Views)

 Background : Peripheral blood fibrocytes are a newly identified circulating leukocyte subpopulation that migrates into injured tissue where it may display fibroblast-like properties and participate in wound healing and fibrosis of skin and other organs. In this study, fibrocyte recruitment to skin in a bleomycin-induced dermal fibrosis model of human scleroderma in vivo was studied.

 Materials and methods : Sections of skin from normal mice ) control group) and bleomycin-treated C57BL/6 mice (Experimental group) were stained for Procollagen α2 Type I and CD34 and the double stained cells, and also fibrocytes were counted in the tissue sections.

 Results : There were more fibrocytes in the dermis of experimental group than control group. There was no significant difference in fibrocyte number between skin samples with 1 week bleomycin treated and 3 weeks treated samples. We also found that fibrocytes (CD34+ and procollagen+) were mainly localized in clusters around blood vessels in the dermis and also individually close to epithelium.

 Conclusion : Our data suggest an important role of fibrocytes in the pathology of dermal fibrosis.

 

Keywords: Fibrocyte, Bleomycin, Dermal fibrosis, Scleroderma.
Full-Text [PDF 459 kb]   (2794 Downloads)    
Semi-pilot: Experimental | Subject: Anatomy
Received: 2011/09/11 | Published: 2011/09/15
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Katebi M, Sharifi Z N, Movassaghi S, Chegini H R, Fazelipoor S, Abbasi Moghadam M A et al . Role of fibrocytes (CD34+) derived from peripheral blood in the pathology of dermal fibrosis in a model of scleroderma. MEDICAL SCIENCES 2011; 21 (2) :97-100
URL: http://tmuj.iautmu.ac.ir/article-1-449-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 21, Issue 2 (summer 2011) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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