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Association of adiponectin gene (rs 2241766) polymorphism and colorectal cancer in Tehran, Iran
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Akram Safaei1   , Khatoon Karimi2 , Maral Arkani2 , Fatemeh Rostami3 , Elham Arbabi4 , Mohsen Vahedi5 , Seyed Reza Mohebi6 , Mohammad Vafaie7 , Seyed Reza Fatemi8 , Mohammad Rezd Zali8 |
1- MSc of Genetic, Research Center for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran , akramsafaei.134@gmail
2- MSc of Microbiology, Research Center for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- MSc of Biochemistry, Research Center for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences, Tehran , Iran
4- MSc of Plant Genetic, Research Center for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5- MSc of Biostatistics, Research Center for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6- PhD of Medical Virology, Research Center for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7- General Surgeon, Iranian Ostomy Society, Tehran, Iran
8- Gastroenterologist, Research Center for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran |
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Abstract: (18203 Views) |
Background: Many studies have been shown association between low level of Adiponectin hormone and insulin resistancy, obesity and increased risk of colorectal cancer. The goal of this study was to evaluate prevalence of polymorphism of Adiponectin gene rs 2241766 in Tehran, Iran and to check the role of this polymorphism in increased risk of colorectal cancer.
Materials and Methods: In this case- control study, genotyping of the Insulin gene were determined in 107 colorectal cancer patients and 107controls by using polymerase chain reaction and restriction fragment length polymorphism genotyping assays (PCR-RFLP).The statistical analysis was done using SPSS ver.16.
Results: Polymorphism of Adiponectin rs 2241766 was not a predisposing factor to increased risk of CRC (p=0.29). The genotype GT compared with TT, was not associated with increased risk of CRC (OR=1.02, CI=0.52-1.97 p=0.95), but GG versus TT (OR=0.015, CI=0.29-0.78 p=0.025) was associated with decreased risk of CRC. Frequency of mutant allele hadn't significant difference between patients and controls (OR=7.34, 95% CI=0.45-1.19 p=0.21).
Conclusion: These findings suggest that polymorphism of adiponectin rs 2241766 isn't associated with increased risk of CRC. |
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| Keywords: Colorectal cancer, Aiponectin gene, PCR–RFLP, Colorectal cancer |
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Full-Text [PDF 187 kb]
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Semi-pilot: case-control |
Subject:
Genetic
Received: 2012/06/26 | Published: 2012/06/15
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Safaei A, Karimi K, Arkani M, Rostami F, Arbabi E, Vahedi M, et al . Association of adiponectin gene (rs 2241766) polymorphism and colorectal cancer in Tehran, Iran. MEDICAL SCIENCES 2012; 22 (2) :110-115 URL: http://tmuj.iautmu.ac.ir/article-1-564-en.html
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