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:: Volume 22, Issue 4 (winter 2013) ::
MEDICAL SCIENCES 2013, 22(4): 266-272 Back to browse issues page
Study of anatomical, histological and biochemical changes of liver in the mice exposed to phenol
Ali Louei Monfared 1, Zahra Tootian2 , Simin Fazelipour3
1- Department of Basic Sciences, Faculty of Veterinary Medicine, University of Ilam, Ilam, Iran , alm722@gmail.com
2- Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
3- Department of Anatomy, Islamic Azad University, Tehran Medical Branch, Tehran, Iran
Abstract:   (15612 Views)
Background: Liver is one of the most important body´s organs which metabolize many of substances such as phenol. This study was done to investigate the probable effects of phenol administration on the histo-anatomical structure and also biochemical functions of the liver.
Materials and Methods: In this experimental study, eighty male Balb/C mice were selected and randomly divided into one control group and three experimental groups. Distilled water was administered through gavage method on the control group and experimental groups received 80, 180 and 320 mg/kg/day of phenol, respectively, for one month. At the end of the experiment, the animals were euthanized by chloroform and the liver was removed from body. Then, absolute and relative weights of liver were recorded. Hepatic tissue samples were taken and histological changes were examined using optical microscopy. Blood samples were also collected and after separating the sera, liver enzyme activities were analyses.
Results: Administrating phenol caused significant elevation in absolute and relative liver weights. Also, phenol treatment induced significant increase of hepatocyte diameter, hepatocyte's nuclear diameter and hepatic sinusoid size (P<0.05). Furthermore, phenol treated animals had leukocyte infiltration, necrosis, congestion and bile duct hyperplasia in comparison with the control group. Phenol treatment caused significant elevation in the serum levels of AST, ALT and ALP (P<0.05).
Conclusion: The present study showed that exposing to the different concentrations of phenol can cause severe damages in the mice's liver.
Keywords: Phenol, Liver, Mice, Histology, Biochemistry
Full-Text [PDF 202 kb]   (3870 Downloads)    
Semi-pilot: Experimental | Subject: Anatomy
Received: 2012/12/24 | Published: 2013/01/15
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Louei Monfared A, Tootian Z, Fazelipour S. Study of anatomical, histological and biochemical changes of liver in the mice exposed to phenol. MEDICAL SCIENCES 2013; 22 (4) :266-272
URL: http://tmuj.iautmu.ac.ir/article-1-621-en.html


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Volume 22, Issue 4 (winter 2013) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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