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Interaction between vitamin A and pilocarpine on memory retention in adult male rats
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Akram Eidi1   , Mahsa Joolaeian2 , Ali Haeri Rohani3 , Tahereh Eshraghi2 |
1- PhD of Animal Physiology, Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Science and Research Branch,Tehran, Iran , eidi@srbiau.ac.ir
2- MSc of Animal Physiology, Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Science and Research Branch,Tehran, Iran
3- PhD of Animal Physiology, Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Science and Research Branch,Tehran, Iran |
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Abstract: (13520 Views) |
Background: Several studies have reported that retinoic acid administration and/or consumption of a vitamin A-enriched diet was could repair the aging induced memory deficits, decreased hippocampal long term potentiation (LTP). Vitamin A deficiency impairs learning ability and hippocampal LTP in mice. In the present study, the effects of the vitamin A and pilocarpine (a muscarinic agonist) on memory retention in adult male rats were investigated.
Materials and methods: Post-training intracerebroventricular injections were carried out in all experiments. Memory retention was evaluated by using a step-through passive avoidance paradigm in adult male rats.
Results: Vitamin A (1000 and 2000 IU/rat) and pilocarpine (1 g/rat) increased memory retention. The acetylcholine receptor agonist (pilocarpine) increased the response to vitamin A. The response to vitamin A was potentiated by pilocarpine.
Conclusion: It is concluded that vitamin A elicits an interaction with the cholinergic system in memory retention. |
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| Keywords: Vitamin A, Pilocarpine, Passive avoidance learning, Rat |
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Full-Text [PDF 193 kb]
(2661 Downloads)
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Semi-pilot: Experimental |
Subject:
Physiology
Received: 2013/03/16 | Accepted: 2013/05/28 | Published: 2013/05/28
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