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Effect of sodium azide on sperm parameters and the serum levels of testosterone, LH and FSH in adult male mice
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Maryam Khosravi1   , Fatemeh Alpaloo2 , Mahsa Hadipourjahromi3 , Shahrzad Khakpour4 |
1- Department of Animal Physiology, Islamic Azad University, North Tehran Branch, Tehran, Iran
2- MSc of Biology – Animal Science, Islamic Azad University, North Tehran Branch, Tehran, Iran , falpaloo@gmail.com
3- Department of Pharmacology, Faculty of Medicine, Research Center of Medical Sciences, Islamic Azad University, Tehran Medical Branch, Tehran, Iran
4- Department of Physiology, Faculty of Medicine, Research Center of Medical Sciences, Islamic Azad University, Tehran Medical Branch, Tehran, Iran |
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Abstract: (12445 Views) |
Background: Sodium azide is a chemical and toxic compound. The aim of this study was to evaluate the effects of sodium azide on the viability of sperms and the serum levels of testosterone, LH and FSH in mature male laboratory small mice.
Materials and Methods:In this experimental study, 50 Balb/C male mice weighing 20-25g were divided into five groups (10 mice in each group). The animals were prescribed sodium azide for 60 days. Alternatively 5, 10 and 20 milligrams per kilogram of body weight of sodium azide were fed to the animals in the experimental groups 1, 2 and 3. After the completion of treatment, serum values of testosterone, LH and FSH were measured. The viability of sperms was also studied.
Results: The number of sperms in three experimental groups showed significant decrease compared to the control and sham groups (p<0.001). Serum value of testostrone hormone showed dose- dependently significant decrease compared to the control and sham groups. The serum level of FSH in the experimental groups did not show any significant change compared to the control and sham groups. But, the serum level of LH in experimental groups receiving sodium azide 10, 20 mg/kg increased significantly compared to the control and sham groups (p<0.01).
Conclusion: It seems sodium azide reduces serum level of testosterone and the number of sperms under the process of spermatogenesis in the animals. |
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| Keywords: Sodium azide, Mice, Spermatogenesis, Testosterone, LH, FSH |
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Full-Text [PDF 233 kb]
(2967 Downloads)
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Semi-pilot: Experimental |
Subject:
Physiology
Received: 2013/06/19 | Published: 2013/06/15
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