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Evaluation of morphologic and macrohistiologic effects of hyaluronic acid, estrogen, honey, and silver nanoparticle on rats with induced peritoneal adhesion
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Naser Rahbar   1, Masoumeh Fatemi2 , Zohreh Davarzani3 |
1- Department of Surgery, Faculty of Medicine, Islamic Azad University, Tehran Medical Branch, Tehran, Iran , naser129@hotmail.com
2- Department of Internal Medicine, Faculty of Medicine, Islamic Azad University, Tehran Medical Branch, Tehran, Iran
3- Department of Surgery, Faculty of Medicine, Islamic Azad University, Tehran Medical Branch, Tehran, Iran |
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Abstract: (9828 Views) |
Background: intra-abdominal adhesion is the most common cause of small bowel obstruction occurring in approximately 65% to 75% of cases. Intra-abdominal adhesion increases re-operation time, blood loss and other complication. In this study, effects of honey, hyaluronic acid, estrogen, and silver nanoparticle were examined against post operative adhesion.
Materials and Methods: In this experimental study, 48 male albino wister rats were divided into 6 groups, each 8 rats. Adhesion was induced by using the cecal abrasion. 40 rats received agents of honey, hyaluronic acid, estrogen, silver nanoparticle, and 8 rats were considered as control group. Two week later, reoperation was performed and adhesion band was evaluated. Sesame oil was the solvent of estrogen, so, we have to choose another group to determine the protective effect of sesame oil.
Results: Hyaluronic acid and sesame oil has had the most protective effect against post operative adhesion compared with control and other groups.
Conclusion: Hyaluronic acid and sesame oil had protective effect against post operative adhesion. |
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| Keywords: Peritoneal adhesion, Honey, Hyaluronic acid, Estrogen, Silver nanoparticle |
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Full-Text [PDF 126 kb]
(2338 Downloads)
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Semi-pilot: Experimental |
Subject:
Surgery
Received: 2013/09/22 | Published: 2013/09/15
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