[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
Webmail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 25, Issue 2 (summer 2015) ::
MEDICAL SCIENCES 2015, 25(2): 79-94 Back to browse issues page
lncRNAs: significance and function mechanisms
Mohammad Reza Noori-Daloii 1, Yeganeh Eshaghkhani2
1- PhD of Medical Molecular Genetics, Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran , nooridaloii@sina.tums.ac.ir
2- PhD Student of Medical Genetics, Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (7924 Views)
In mammals, the majority of products of gene expression are non-coding ribonucleotide sequences. They include short and long RNA molecules with sizes ranging of tens to hundreds of nucleotides. Among them, the molecules with more than 200 nucleotides are called long non-coding RNAs or lncRNAs. While LncRNAs functions depend on their unique molecular structures, they play important roles in regulating gene expression at epigenetic, transcriptional and post-transcriptional levels. Interacting with other biological molecules such as DNA, RNA and protein, LncRNAs have been found to play important roles in normal cell physiological activities. Activation of transcription factors, guidance of ribonucleoprotein complexes, aggregation of partner proteins, regulation of alternative processing, cooperation in chromatin remodeling, facilitation of genomic imprinting, maintaining of multipotential state and control of nucleus/cytoplasm traffic are some of crucial approaches Implemented by LncRNAs. Modern technologies have been developed to identify lncRNA molecules, and many relevant databases have been designated to facilitate research and academic exchange of data concerning them. In this review article, signification, identification, classification, biological evolution, genomic position, configuration, expression, localization and remarkable functions of LncRNAs have been discussed.
 Keywords: ncRNA, lncRNA, Function.
Keywords: ncRNA, lncRNA, Function
Full-Text [PDF 929 kb]   (27028 Downloads)    
Semi-pilot: Review | Subject: Genetic
Received: 2015/06/16 | Accepted: 2015/06/16 | Published: 2015/06/16
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Noori-Daloii M R, Eshaghkhani Y. lncRNAs: significance and function mechanisms. MEDICAL SCIENCES 2015; 25 (2) :79-94
URL: http://tmuj.iautmu.ac.ir/article-1-935-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 25, Issue 2 (summer 2015) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
Persian site map - English site map - Created in 0.06 seconds with 37 queries by YEKTAWEB 4660