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In vivo study of the effect of kombucha on the injured skin of adult NMRI mice strain
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Kazem Parivar1   , Parichehr Yaghmaei2 , Shokouh Heidari 3 |
1- Professor, Department of Animal Biology, Islamic Azad University, Science and Research Campus, Tehran, Iran
2- Assistant Professor, Department of Animal Biology, Islamic Azad University, Science and Research Campus, Tehran, Iran
3- MSc of evolutionary Biology, Islamic Azad University, Science and Research Campus, Tehran, Iran , shokuh_jim@yahoo.com |
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Abstract: (16593 Views) |
Background: Kombucha is used for the treatment of several diseases, including wound healing, in traditional medicine. Due to its effective abilities, such as antibiotic activities, detoxification, and its impact on skin luminosity, we attempted to determine its effect on injured skin in in vivo condition.
Materials and methods: 30 male NMRI strain were randomly assigned in control (injured skin), sham (exposed with sweet tea) and experimental (received Kombucha) groups. A 3mm diameter wound with complete skin thickness was made on the back of each mouse. Treatment with Kombucha was applied three times a day for 18 days. At the end of study, histological study was carried out on the under-treatment tissues.
Results: Significant decrease in wound diameter was observed in experimental group compared to control group (P<0.001). Furthermore, significant increased epidermal thickness and decreased derm and hypoderm thickness were seen in experimental group compared to control group (P<0.05). Hair follicle diameter was significantly increased in experimental group compared to control group, while skin thickness diameter was in coordination with control group.
Conclusion: External use of Kombucha on open wound skin with complete skin thickness effectively accelerates wound-healing procedure and also increases hair follicle diameter and length in in vivo condition. |
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| Keywords: Kombucha, Injured skin, Wound healing |
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Full-Text [PDF 437 kb]
(3887 Downloads)
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Semi-pilot: case-control |
Subject:
Animal Biology
Received: 2012/02/15 | Published: 2012/02/15
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