Abstract: Neurofibromatosis is a genetic disorder presented with tumoral tissue around a nerve and other pathologic disorders. Neurofibromatosis type I (NF1) is more frequent and involves skin, central nervous system, bone and endocrine glands. Neurofibromatosis type II (NF2) is, however, presented with bilateral acoustic neuroma. Neurofiromatosis type V (NF5) is a rare disorder that has been reported in only 100 cases worldwide and presents with cutaneous neurofibromas with or without skin lesions. In the present article we have introduced 2 females aged 19 and 20 with segmental neurofibromatosis.