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:: Volume 16, Issue 4 (Winter 2006) ::
MEDICAL SCIENCES 2006, 16(4): 231-235 Back to browse issues page
Surveying Acyclovir side effects on developing embryos of Balb/C mice strain
Kazem Parivar 1, Homa Mohsenikouchesfahani , Baharak MOhammadzadehasl
1- , kazem-parivar@yahoo.com
Abstract:   (61957 Views)
Background: Acyclovir is a drug used to treat herpes virus infections including cold catch injuries, hot spots of genital organs, zona, AIDS, chicken pox and some other viral infections. The local cream of acyclovir is prepared in %5 packages, each gram containing 50mg of drug in a base of polyethylene glycol.
Materials and methods: Acyclovir cream (%5) in days 7, 8 and 9 of gestation was applied around their mouth (experimental group 1) and to the shared skin of other group (experimental group 2) twice a day in two hours intervals. Pregnant mice were sacrificed and dissected on day 15 of gestation and morphological and histological studies on the embryos and placenta were carried out. In the case of non-pregnant mice, the uteral born and ovaries were processed for histological investigations.
Results: Histological analyses showed significant decrease in embryogenesis and significant increase of abortion in experimental group 1 compared with control group. Significant increment was found in uterus diameter and thickness of endometrium when compared with control group.
 Conclusion: A pregnant woman should be very careful about applying acyclovir during the first trimester of pregnancy.
Keywords: Acyclovir, Embryogenesis, Abortion, Organogenesis.
Full-Text [PDF 248 kb]   (5448 Downloads)    
Subject: Epidemiology
Received: 2006/09/6 | Published: 2006/12/15
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Parivar K, Mohsenikouchesfahani H, MOhammadzadehasl B. Surveying Acyclovir side effects on developing embryos of Balb/C mice strain. MEDICAL SCIENCES 2006; 16 (4) :231-235
URL: http://tmuj.iautmu.ac.ir/article-1-106-en.html

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Volume 16, Issue 4 (Winter 2006) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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