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Association of rs2274907 polymorphism of omentin gene with type 2 diabetes in Iranian population
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Arezo Nazari1    , Mahnaz Mohammadi 2, Masoumeh Nezhadali Lamfjani3 , Tahereh Naji4 |
1- MSC, Department of Biotechnology, Faculty of Biotechnology, Medicine Branch, Azad University, Tehran, Iran
2- Assistant Professor, Department of Biology, Faculty of Biological Sciences Islamshahr Branch, Azad University, Islamshahr, Tehran, Iran , mh_mohamadi@yahoo,com
3- Assistant Professor, Department of Biology, Faculty of Biological Sciences Islamshahr Branch, Azad University, Islamshahr, Tehran, Iran
4- Associate Professor, Faculty of Biological Sciences, Department of Biology Medicine Branch, Azad University, Tehran, Iran |
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Abstract: (1589 Views) |
Background: Diabetes is one of the most common chronic metabolic diseases in the world that is caused by decreased insulin secretion or insulin resistance and fat accumulation in visceral adipose tissue (IR). Omentin is a protein inferred from adipose tissue that is associated with the rate of diabetes. The aim of this study was to investigate the relationship between rs2274907 polymorphism of amentine-1 gene with diabetes.
Materials and methods: This case-control study was conducted on 70 patients with diabetes and 70 healthy individuals as control. FBS, TG, CHOL, HDL, and LDL were measured in the subjects and genotype determination was performed using PCR-RFLP.
Results: Age, body mass index, LDL, cholesterol, triglyceride, fasting high sugar and insulin resistance were significantly different between patients and healthy individuals (p<0.05). No significant difference was observed in omentin level in diabetic compared to control patients (p>0.05). Omentin levels in different genotypes rs2274907 were different in healthy subjects, but the difference was not significant. Omentin levels in different genotypes rs2274907 were different in healthy subjects (p<0.05). Genotype regression analysis showed that genotypes in rs2274907 polymorphism were not related to diabetes (p>0.05).
Conclusion: This study revealed that there was no significant relationship between rs2274907 genotype and type 2 diabetes.
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| Keywords: Type 2 diabetes, Adipokine, Omentin gene, Insulin resistance |
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Full-Text [PDF 661 kb]
(600 Downloads)
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Semi-pilot: Experimental |
Subject:
biotechnology
Received: 2021/07/17 | Accepted: 2021/10/19 | Published: 2022/03/21
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| References |
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Nazari A, Mohammadi M, Nezhadali Lamfjani M, Naji T. Association of rs2274907 polymorphism of omentin gene with type 2 diabetes in Iranian population. MEDICAL SCIENCES 2022; 32 (1) :44-52 URL: http://tmuj.iautmu.ac.ir/article-1-1915-en.html
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