[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 32, Issue 3 (Fall 2022) ::
MEDICAL SCIENCES 2022, 32(3): 264-271 Back to browse issues page
Formulation and physicochemical control of mupirocin emulsion
Shahrzad Akbari1, Ramin Asgharian 2
1- MSc of Pharmaceitics, Faculty of Pharmaceutics, Tehran Medical Science, Islamic Azad University, Tehran, Iran
2- Industrial pharmacy, Faculty of pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran , asgharian.r@iaups.ac.ir
Abstract:   (149 Views)
Background: The aim of this study was to develop a stable skin emulsifier from mupirocin.
Materials and methods: This study was performed in the Department of Pharmacy, Tehran University of Pharmaceutical Sciences from November 2016 to September 2015. Initially, preformulation studies were performed on mupirocin powder and a standard diagram was drawn. Next, the bases of the drug-free emulsifiers were made, their stability was investigated and the superior formulation was selected. The next step was the formulation of the emulsion containing the drug. Further studies such as determining the amount of active ingredient, releasing the drug in vitro and determining the aura of stunting were performed.
Results: Emulsifier containing 940 carbomer, 5% liquid paraffin, 0.4% tween 20 and 1.1% spin 20 were selected as the top formulation. The results of stability, dispersibility and other tests were appropriate. The amount of active ingredient in the formulations was between 90 and 110%. Within 8 hours, the drug was released at approximately 85%. Rheologically, the formulation followed non-Newtonian behavior. It also showed the behavior of plastics and thixotropes. Observing the growth inhibition zone around drug-containing formulations indicateed that mupirocin was released from the emulsion base and prevented the growth of Staphylococcus aureus bacteria.
Conclusion: A stable emulsion formulation can be prepared from mupirocin. It is suggested that accelerated stability studies and periodic and scale-up formulations be carried out for industrial production.
 
Keywords: Emulsion, Topical, Dermal, Mupirocin
Full-Text [PDF 303 kb]   (67 Downloads)    
Semi-pilot: Semi-pilot | Subject: Pharmacology
Received: 2022/01/5 | Accepted: 2022/08/6 | Published: 2022/09/1
References
1. Talat M, Zaman M, Khan R, Jamshaid M, Akhtar M, Mirza AZ. Emulgel: an effective drug delivery system. Drug Dev Ind Pharm 2021;47: 1193-99. [DOI:10.1080/03639045.2021.1993889]
2. Khullar R, Kumar D, Seth N, Saini S. Formulation and evaluation of mefenamic acid emulgel for topical delivery. Saudi Pharmaceut J 2012;20:63-7. [DOI:10.1016/j.jsps.2011.08.001]
3. Allen L, Ansel HC, eds. Ansel's pharmaceutical dosage forms and drug delivery systems. London: Lippincott Williams & Wilkins; 2013.
4. Yassin GE. Formulation and evaluation of optimized clotrimazole emulgel formulations. J Pharmaceut Res Int 2014:1014-30. [DOI:10.9734/BJPR/2014/8495]
5. Sawant AA, Mohite SK. Formulation and evaluation of itraconazole emulgel for topical drug delivery. Asian J Pharm Technol 2015;5:91-6. [DOI:10.5958/2231-5713.2015.00014.8]
6. Ferreira SBS, Slowik KM, Castro Hoshino LV, Baesso ML, Murdoch C, Colley HE, et al. Mucoadhesive emulgel systems containing curcumin for oral squamous cell carcinoma treatment: From pre-formulation to cytotoxicity in tissue-engineering oral mucosa. Eur J Pharm Sci 2020;151: 105372. [DOI:10.1016/j.ejps.2020.105372]
7. Torregrosa A, Ochoa-Andrade AT, Parente ME, Vidarte A, Guarinoni G, Savio E. Development of an emulgel for the treatment of rosacea using quality by design approach. Drug Dev Ind Pharm 2020;46:296-308. [DOI:10.1080/03639045.2020.1717515]
8. Sharma G, Sharma M, Sood R, Neelamraju J, Lakshmi SG, Madempudi RS, et al. Self-preserving gelatin emulgel containing whole cell probiotic for topical use: preclinical safety, efficacy, and germination studies. Expert Opin Drug Deliv 2021;18: 1777-89. [DOI:10.1080/17425247.2021.1947239]
9. Lamb YJ. Overview of the role of mupirocin. J Hosp Infect 1991;19:27-30. [DOI:10.1016/0195-6701(91)90199-I]
10. Allen L, Ansel HC. Ansel's pharmaceutical dosage forms and drug delivery systems. Lippincott Williams & Wilkins; 2013 Dec 23.
11. Taylor KM, Aulton ME, eds. Aulton's Pharmaceutics E-Book: The Design and Manufacture of Medicines. New York: Elsevier Health Sciences; 2021.
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Akbari S, Asgharian R. Formulation and physicochemical control of mupirocin emulsion. MEDICAL SCIENCES 2022; 32 (3) :264-271
URL: http://tmuj.iautmu.ac.ir/article-1-1962-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 32, Issue 3 (Fall 2022) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
Persian site map - English site map - Created in 0.05 seconds with 30 queries by YEKTAWEB 4509