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:: Volume 32, Issue 3 (Fall 2022) ::
MEDICAL SCIENCES 2022, 32(3): 320-327 Back to browse issues page
Correlation between anti-nuclear antibodies (ANA), rheumatoid factor (RF), anti-cyclic citrullinated peptides antibodies (Anti-CCP) and percentage and type of pulmonary involvement in patients with rheumatoid arthritis, Booali Hospital Tehran (2016-2021)
Maedeh Olya1 , Shahla Abolghasemi 2
1- General Practitioner, Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2- Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran , Iran , shahlamarmin@yahoo.com
Abstract:   (597 Views)
Background: Controlling the pulmonary involvement, as one of the most common extra-articular consequences in rheumatoid arthritis (RA), can improve the life quality and survival rate of patients. This study aimed to evaluate the correlation between disease-related inflammatory factors and the severity and type of lung involvement in patients, which is a practical step toward early detection and treatment of RA-related pulmonary problems.
Materials and methods: During 2016-2021, 310 RA patients with pulmonary involvement-related symptoms were studied at Booali Hospital in Tehran. During four separate visits, patients' demographic information and inflammatory factors such as anti-nuclear antibodies (ANA), rheumatoid factor (RF), and anti-cyclic citrulline antibodies (Anti-CCP) were assessed. High-resolution CT scans and chest radiographs were performed on all patients. Data were analyzed using SPSS21 software. P<0.05 was considered as the significance level.
Results: Patients with and without pulmonary involvement had a mean age of 54±13 and 49±13 years, respectively. 35 patients (45.4%) had interstitial lung disease, 21 patients (27.2%) had pulmonary nodules, 3 patients (4%) had atelectasis, 11 patients (14.3%) had bronchitis, and 7 patients (9.1 %) had pulmonary fibrosis and emphysema. Correlation between anti-CCP and RF inflammatory factors and the prevalence and type of pulmonary involvement was significant (P<0.05). There was no statistically significant difference between the ANA index and demographic data among RA patients with pulmonary involvement.
Conclusion: Inflammatory factors including anti-CCP and RF may help predict the severity and pulmonary complications prognosis in RA patients.
Keywords: RF, Anti-CCP, ANA, Pulmonary involvement, Rheumatoid arthritis
Full-Text [PDF 330 kb]   (173 Downloads)    
Semi-pilot: Survey/Cross Sectional/Descriptive | Subject: Romatology
Received: 2021/12/29 | Accepted: 2022/04/10 | Published: 2022/09/19
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Olya M, Abolghasemi S. Correlation between anti-nuclear antibodies (ANA), rheumatoid factor (RF), anti-cyclic citrullinated peptides antibodies (Anti-CCP) and percentage and type of pulmonary involvement in patients with rheumatoid arthritis, Booali Hospital Tehran (2016-2021). MEDICAL SCIENCES 2022; 32 (3) :320-327
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Volume 32, Issue 3 (Fall 2022) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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