|
Evaluation of gamma glutamyl transferase level in colonoscopy patients with or without adenoma referred to gastroenterology clinic in Azad University Hospitals between 2021 and 2022
|
Sara Sabouri    , Amir Taheri1 , Shima Mosalanejad2 , Fatemeh Mikaniki , Arezoo Chouhdari3 |
1- Assistant Professor, Department of Internal Medicine, Gastroenterology Specialist, Farhikhtegan Hospital, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran , dr.Amir.taheri@gmail.com
2- Assistant Professor of Internal Medicine Department, Internal Medicine Specialist, Bo Ali Hospital, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
3- Assistant Professor, Department of Social Medicine, Specialist in Preventive Medicine and Social Medicine, Amirul Mominin Hospital, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran |
|
|
Abstract: (580 Views) |
Background: Colon cancer is one of the most common cancers in the world, and today screening with colonoscopy plays a significant role in early detection and prevention of the progression of this cancer. Materials and methods: This retrospective and cross-sectional study was done on 160 patients referred to gastroenterology clinics who have indications for colonoscopy according to criteria. Based on the presence or absence of adenoma in the colonoscopy, the patients were divided into two groups. The serum level of gamma glutamyl transferase was checked in the adenoma and non-adenoma groups, and the results were compared. Gamma glutamyl level above 32 U/l in women and 49 U/l in men was considered as the cut-off level. The results were analyzed with SPSS software. Results: No significant correlation was observed between age and Gamma GT level (R=0.031) and there was no significant relationship between gender and Gamma GT level (p: 0.58). But on the other hand, a significant relationship was found between having an adenoma and high gamma GT levels (p: 0.002). Conclusion: According to results, it can be concluded that age and gender factors do not relate to the high level of gamma GT, but the relationship between this enzyme and adenoma was significant. Therefore, it can be said that the high level of gamma GT is an influential factor in having adenoma. |
|
| Keywords: Colon cancer, Adenoma, Gamma GT enzyme |
|
|
Full-Text [PDF 593 kb]
(176 Downloads)
|
Semi-pilot: Survey/Cross Sectional/Descriptive |
Subject:
Gastrology
Received: 2024/04/2 | Accepted: 2024/05/13 | Published: 2025/03/30
|
|
|
|
|
|
|
| References |
1. Hill Mj, Morson BC, Bussey Hy. Aetiology of adeno-cercinomn Sequence in large bowel. Lancet 1978 4;1:245-7. [ DOI:10.1016/S0140-6736(78)90487-7] 2. Koenig G, Seneffs, Gamma Glutamyl transferase: Apredictive Biomarker of Cellumar Antioxidant Inadequacy and Disease Risk. Dis markers 2015:818570. [ DOI:10.1155/2015/818570] 3. Cotri A, Franzin M, paolicchi A, pompella A. Gamma glutamyl transferese of cancer cells at the crossroads of tumor progression Drag resistance and Drug targeting. Anti-cancer Res 2010;30:1169-81. 4. Polterauer a, Hofstetter b, Grimm c, Rahhal c, Mailath-Pokorny c, Maria K, et.al. Relevance of gamma glutamyl transferasea marker for Apoptotic balance-in predicting tumor stage and prognosis in cervical cancer. Gynecol Oncol .2011:122:590-4. [ DOI:10.1016/j.ygyno.2011.05.027] 5. Abbasi R, Durdi Q, Hajihosseini R, Hosseini V. Evaluation of the Correlation between the Alteration of Specific Biochemical Indicators levels in the Early Stages of Colorectal Cancer, Journal of Gourgan university of medical sciences,2021; 23: 47-51. [In Persian] 6. Fiala S, Fiala AE, Keller RW, Fiala ES. GGT in colon cancer induced by 1,2- dimethyl hydrazine. Arch Geschwulstforsch 1977;47:117-22. 7. Chiko S, Seiichiro A, Yutaka S, Eriko S, Hiroyuki T, Makomo M, et al. A pilot study of fluorescent imaging of colorectal tumors using a GGT. Digestion 2015;91:70-6. [ DOI:10.1159/000369367] 8. Huijie W, Huanwei Z, Xu C, Ping M, Jinli L, Haiying Z, et al. Association between serum γ-glutamyl transferase and advanced colorectal adenoma among inpatients: a case-control study. Front Oncol 2024 Jan 12;13:1188017. [ DOI:10.3389/fonc.2023.1188017] 9. Tzu-Chan H, Hung-Chih Y, Chi-Ling C, Jia-Horng K, Chun-Jen L, Ming-Jen C, et al. Relationship between serum GGT level and colorectal Adenoma, PLos One 2020;15:e0240455. 10. Li-Xiang Z, Yang L, A-Man X, Huan-Zhong W. The prognostic significance of serum GGT levels and AST/ALT in primary hepatic carcinoma BMC Cancer 2019;19;841. [ DOI:10.1186/s12885-019-6011-8] 11. Binyi X, Jianhong P, Jinghua T, Yuxiang D, Yujie Z, Xiaojun Wu, et al. Serum Gamma Glutamyl transferase is a predictor of recurrence after R0 hepatectomy for patients with colorectal cancer liver metastases. Ther Adv Med Oncol 2020; 12: 1758835920947971. [ DOI:10.1177/1758835920947971] 12. Yejin M, Dong-Koog S, Young Duk Y, Sun Ha J, Jonathan MS. GGT and cancer RSK: the Korean cancer prevention study: Int J Cancer 2016;138:311-9. [ DOI:10.1002/ijc.29659] 13. 13 Mieke Van H, Wayel J, Goran W, Ian S F, Niklas H, Mats L, et al. GGT and risk of cancer in cohort of 545,460 persons - the Swedish AMORI S study. Eur J Cancer 2011;47):2033-41. [ DOI:10.1016/j.ejca.2011.03.010] |
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
|
Sabouri S, Taheri A, mosalanejad S, Mikaniki F, Chouhdari A. Evaluation of gamma glutamyl transferase level in colonoscopy patients with or without adenoma referred to gastroenterology clinic in Azad University Hospitals between 2021 and 2022. MEDICAL SCIENCES 2025; 35 (1) :65-69 URL: http://tmuj.iautmu.ac.ir/article-1-2222-en.html
|
