|
Metal-organic framework Zn2(bdc)2(dabco) nano vehicle hepatotoxicity in female Wistar albino rats
|
Farzad Rahmani1   , Pejman Mortazavi2 , Negar Motakef Kazemi3 , Zahra Jafariazar4 , Zahra Mousavi5  |
1- PhD candidate in Toxicology, Department of Pharmacology and Toxicology, TeMS.C., Islamic Azad University, Tehran, Iran
2- Department of Veterinary Pathobiology, SR.C., Islamic Azad University, Tehran, Iran
3- Department of Medical Nanotechnologies, TeMS.C., Islamic Azad University, Tehran, Iran
4- Department of Pharmaceutics, TeMS.C., Islamic Azad University, Tehran, Iran
5- Professor in Toxicology, Department of Pharmacology and Toxicology, TeMS.C., Islamic Azad University, Tehran, Iran , mosavi50@yahoo.com |
|
|
Abstract: (277 Views) |
Background: In the last decade, metal-organic frameworks have been considered as new drug delivery systems due to their unique properties such as high porosity, very large specific area and biocompatibility. New drug delivery systems based on metal-organic frameworks lead to the release of active pharmaceutical ingredients to achieve a therapeutic response. The purpose of this study was to evaluate the sub-chronic hepatotoxicity of metal-organic framework Zn2 (bdc)2(dabco) as a drug carrier for a new drug delivery system.
Materials and methods: In this experimental study, 24 female Wistar rats were divided into four groups, including control group and three groups receiving Zn2 (bdc)2(dabco) with doses of 50, 100, 200mg/kg orally for 28 days. Changes in water and food consumption, body weight, liver weight, levels of alkaline phosphatase, aspartate transaminase and alanine transaminase enzymes and liver histopathology were evaluated.
Results: There were no changes in water and food consumption, body weight and liver weight in any of the groups. A significant increase in ALP and mild necrotic and inflammatory changes were observed only in the group receiving 200mg/kg dose (p<0.05), but no enzymatic and histopathological changes were observed in the other groups compared to the control group.
Conclusion: Metal-organic framework Zn2 (bdc)2(dabco) with a dose of 200mg/kg leads to liver damage, although it did not show any toxicity in low doses; so it can be used in low concentration with maximum drug loading capacity as a nano-carrier in the new drug delivery system. |
|
| Keywords: Metal-organic framework Zn2 (bdc)2(dabco), sub-chronic toxicity, liver tissue |
|
|
Full-Text [PDF 1071 kb]
(79 Downloads)
|
Semi-pilot: Basic |
Subject:
Pharmacology
Received: 2024/04/13 | Accepted: 2024/07/13 | Published: 2025/05/31
|
|
|
|
|
|
|
| References |
1. Patra JK, Das G, Fraceto LF, Campos EVR, Rodriguez-Torres MdP, Acosta-Torres LS, et al. Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnol 2018;16:1-33. [ DOI:10.1186/s12951-018-0392-8] 2. Sharma P, Mehta M, Dhanjal DS, Kaur S, Gupta G, Singh H, et al. Emerging trends in the novel drug delivery approaches for the treatment of lung cancer. Chem Biol Interact 2019;309:108720. [ DOI:10.1016/j.cbi.2019.06.033] 3. Bhutani U, Basu T, Majumdar S. Oral drug delivery: conventional to long acting new-age designs. Eur J Pharm Biopharm 2021;162:23-42. [ DOI:10.1016/j.ejpb.2021.02.008] 4. Kulinsky L, Madou M. BioMEMs for drug delivery applications. In: Bhansali S, Vasudev A, eds. MEMS for Biomedical Applications. Sawston, United Kingdom: Woodhead Publishing; 2012. p.218-68. [ DOI:10.1533/9780857096272.3.218] 5. Motakef-Kazemi N, Shojaosadati SA, Morsali A. In situ synthesis of a drug-loaded MOF at room temperature. Microporous and Mesoporous Materials 2014;186:73-9. [ DOI:10.1016/j.micromeso.2013.11.036] 6. Kotcherlakota R, Das S, Patra CR. Therapeutic applications of green-synthesized silver nanoparticles. In: Kumar Shukla A, Iravani S, eds. Micro and Nano Technologies, Green Synthesis, Characterization and Applications of Nanoparticles. Amsterdam, Netherlands: Elsevier; 2019. p.389-428. [ DOI:10.1016/B978-0-08-102579-6.00017-4] 7. Kitagawa S. Metal-organic frameworks (MOFs). Chem Soc Rev 2014;43:5415-8. [ DOI:10.1039/C4CS90059F] 8. Gangu KK, Maddila S, Mukkamala SB, Jonnalagadda SB. A review on contemporary metal-organic framework materials. Inorganica Chimica Acta 2016;446:61-74. [ DOI:10.1016/j.ica.2016.02.062] 9. Lawson HD, Walton SP, Chan C. Metal-organic frameworks for drug delivery: a design perspective. ACS Appl Mater Interfaces 2021;13:7004-20. [ DOI:10.1021/acsami.1c01089] 10. Lee J, Farha OK, Roberts J, Scheidt KA, Nguyen ST, Hupp JT. Metal-organic framework materials as catalysts. Chem Soc Rev 2009;38:1450-9. [ DOI:10.1039/b807080f] 11. Baek J, Rungtaweevoranit B, Pei X, Park M, Fakra SC, Liu Y-S, et al. Bioinspired metal-organic framework catalysts for selective methane oxidation to methanol. J Am Chem Soc 2018;140:18208-16. [ DOI:10.1021/jacs.8b11525] 12. Ghanbari T, Abnisa F, Daud WMAW. A review on production of metal organic frameworks (MOF) for CO2 adsorption. Sci Total Environ 2020;707:135090. [ DOI:10.1016/j.scitotenv.2019.135090] 13. Ge X, Wong R, Anisa A, Ma S. Recent development of metal-organic framework nanocomposites for biomedical applications. Biomaterials 2022;281:121322. [ DOI:10.1016/j.biomaterials.2021.121322] 14. Motakef-Kazemi N, Shojaosadati SA, Morsali A. Evaluation of the effect of nanoporous nanorods Zn 2 (bdc) 2 (dabco) dimension on ibuprofen loading and release. Journal of the iranian chemical society. 2016;13:1205-12. doi.org/10.1007/s13738-016-0835-9 [ DOI:10.1007/s13738-016-0835-9] 15. Rahvar Y, Motakef-Kazemi N, Hosseini Doust R. Synthesis of Zn2 (BDC) 2 (DABCO) MOF by solution and solvothermal methods and evaluation of its anti-bacterial. Nanomed Res J 2021;6:360-8. 16. Rahmani F, Jafariazar Z, Mousavi Z, Kazemi NM. Synthesis of Zn2 (BDC) 2 (DABCO) Metal-Organic Framework and Its Polyethylene Glycol Composite for Acetaminophen Delivery. Iranian Journal of Science. 2024;48:1-11. [ DOI:10.1007/s40995-023-01544-1] 17. Organisation for Economic Co-operation and Development (OCED). Test no. 407: repeated dose 28-day oral toxicity study in rodents. Paris: OECD Publishing; 2008. 18. Lan S, Zhang J, Li X, Pan L, Li J, Wu X, et al. Low toxicity of metal-organic framework MOF-74 (Co) nano-particles in vitro and in vivo. Nanomaterials 2022;12:3398. [ DOI:10.3390/nano12193398] 19. Chen G, Leng X, Luo J, You L, Qu C, Dong X, et al. In vitro toxicity study of a porous iron (III) metal-organic framework. Molecules 2019;24:1211. [ DOI:10.3390/molecules24071211] 20. Ren F, Yang B, Cai J, Jiang Y, Xu J, Wang S. Toxic effect of zinc nanoscale metal-organic frameworks on rat pheochromocytoma (PC12) cells in vitro. J Hazard Mater 2014;271:283-91. [ DOI:10.1016/j.jhazmat.2014.02.026] 21. Baati T, Njim L, Neffati F, Kerkeni A, Bouttemi M, Gref R, et al. In depth analysis of the in vivo toxicity of nanoparticles of porous iron (III) metal-organic frameworks. Chem Sci 2013;4:1597-607. [ DOI:10.1039/c3sc22116d] 22. Liu C-H, Chiu H-C, Sung H-L, Yeh J-Y, Wu KC-W, Liu S-H. Acute oral toxicity and repeated dose 28-day oral toxicity studies of MIL-101 nanoparticles. Regul Toxicol Pharmacol 2019;107:104426. [ DOI:10.1016/j.yrtph.2019.104426] |
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
|
Rahmani F, Mortazavi P, Motakef Kazemi N, Jafariazar Z, Mousavi Z. Metal-organic framework Zn2(bdc)2(dabco) nano vehicle hepatotoxicity in female Wistar albino rats. MEDICAL SCIENCES 2025; 35 (2) :136-144 URL: http://tmuj.iautmu.ac.ir/article-1-2241-en.html
|
