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Metal-organic framework Zn2(bdc)2(dabco) nano vehicle hepatotoxicity in female Wistar albino rats
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Farzad Rahmani1   , Pejman Mortazavi2 , Negar Motakef Kazemi3 , Zahra Jafariazar4 , Zahra Mousavi5  |
1- PhD candidate in Toxicology, Department of Pharmacology and Toxicology, TeMS.C., Islamic Azad University, Tehran, Iran
2- Department of Veterinary Pathobiology, SR.C., Islamic Azad University, Tehran, Iran
3- Department of Medical Nanotechnologies, TeMS.C., Islamic Azad University, Tehran, Iran
4- Department of Pharmaceutics, TeMS.C., Islamic Azad University, Tehran, Iran
5- Professor in Toxicology, Department of Pharmacology and Toxicology, TeMS.C., Islamic Azad University, Tehran, Iran , mosavi50@yahoo.com |
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Abstract: (99 Views) |
Background: In the last decade, metal-organic frameworks have been considered as new drug delivery systems due to their unique properties such as high porosity, very large specific area and biocompatibility. New drug delivery systems based on metal-organic frameworks lead to the release of active pharmaceutical ingredients to achieve a therapeutic response. The purpose of this study was to evaluate the sub-chronic hepatotoxicity of metal-organic framework Zn2 (bdc)2(dabco) as a drug carrier for a new drug delivery system.
Materials and methods: In this experimental study, 24 female Wistar rats were divided into four groups, including control group and three groups receiving Zn2 (bdc)2(dabco) with doses of 50, 100, 200mg/kg orally for 28 days. Changes in water and food consumption, body weight, liver weight, levels of alkaline phosphatase, aspartate transaminase and alanine transaminase enzymes and liver histopathology were evaluated.
Results: There were no changes in water and food consumption, body weight and liver weight in any of the groups. A significant increase in ALP and mild necrotic and inflammatory changes were observed only in the group receiving 200mg/kg dose (p<0.05), but no enzymatic and histopathological changes were observed in the other groups compared to the control group.
Conclusion: Metal-organic framework Zn2 (bdc)2(dabco) with a dose of 200mg/kg leads to liver damage, although it did not show any toxicity in low doses; so it can be used in low concentration with maximum drug loading capacity as a nano-carrier in the new drug delivery system. |
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| Keywords: Metal-organic framework Zn2 (bdc)2(dabco), sub-chronic toxicity, liver tissue |
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Full-Text [PDF 1071 kb]
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Subject:
Pharmacology
Received: 2024/04/13 | Accepted: 2024/07/13 | Published: 2025/05/31
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