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Evaluating the frequency of CMV DNA in the blood of HIV-positive individuals
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Reihaneh Kazemi1    , Kazem Baesi2 , Mohammadreza Aghasadeghi2 , Seyed Amir Sadeghi2 , Mojtaba Hamidi-Fard3 |
1- Department of Genetics, NT.C., Islamic Azad University, Tehran, Iran
2- Hepatitis and AIDS Department, Pasteur Institute of Iran, Tehran, Iran
3- Hepatitis and AIDS Department, Pasteur Institute of Iran, Tehran, Iran , mojtaba_hamidifard@yahoo.com |
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Abstract: (83 Views) |
Background: HIV virus is known as one of the most important pathogenic viruses in human societies, which causes several kinds of opportunistic infections in patients due to immunodeficiency. One of the most important opportunistic viruses in these people is the CMV, which causes serious damage and shortens their lifespan. For this reason, rapid diagnosis of CMV in HIV positive people is important. In this research, it was shown that with a simple test in HIV positive people, it is possible to check the presence of CMV and prevent the deterioration of their disease.
Materials and methods: In this study, 200 plasma samples (147 males and 53 females) of HIV-positive people were collected and the frequency of CMV-DNA was checked by real-time PCR method. Then, the data were studied and analyzed through SPSS software, and the association between age and sex with the frequency of CMV was determined.
Results: The overall frequency of CMV-DNA was found to be around 59%, which is a relatively high prevalence considering the wide age range of the investigated subjects. This frequency was observed in the age groups of 16-30 and 31-45 years and in men more than women.
Conclusion: It was shown that due to the high prevalence of CMV in HIV-positive people, more attention should be paid to the investigation of CMV using molecular tests in these people, and it is possible to reduce life shortening and serious damage caused by CMV.
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| Keywords: CMV, HIV, AIDS, Real-time PCR. |
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Full-Text [PDF 643 kb]
(13 Downloads)
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Semi-pilot: Survey/Cross Sectional/Descriptive |
Subject:
Virology
Received: 2024/07/10 | Accepted: 2024/09/23 | Published: 2025/05/31
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