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Evaluation of the effect of vitamin D on changes in anti TPO antibody levels in patients with Hashimoto's hypothyroidism
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Ghazal Damadi1    , Shahla Abolghasemi2 , Alireza Arefzadeh3 , Mohamad Zare4 , Marjan Golabshekar5 |
1- Internal Medicine Resident, TeMS.C., Islamic Azad University, Tehran, Iran
2- Assistant Professor of Internal Medicine, Rheumatology Subspeciality, Bu-Ali Hospital, TeMS.C., Islamic Azad University, Tehran, Iran , shahlamarmin@yahoo.com
3- Assistant Professor of Internal Medicine, Endocrinology and Metabolism Subspeciality, Farhikhtegan Hospital, TeMS.C., Islamic Azad University, Tehran, Iran
4- Assistant Professor of Epidemiology, Department of Epidemiology, TeMS.C., Islamic Azad University, Tehran, Iran
5- Assistant Professor of Internal Medicine, Bu-Ali Hospital, TeMS.C., Islamic Azad University, Tehran, Iran |
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Abstract: (67 Views) |
Background: Hashimoto's thyroiditis (HT) is the predominant form of autoimmune thyroiditis. This study was designed with the aim of evaluating the effect of vitamin D on changes in Anti TPO antibody levels in patients with Hashimoto's hypothyroidism.
Materials and methods: This quasi-experimental study with before and after design was conducted on 52 patients with Hashimoto's thyroiditis T. The diagnosis of disease was confirmed by an endocrinologist based on the clinical symptoms of hypothyroidism and the increase of Anti TPO antibody (≥38 IU/ml). All patients received vitamin D supplements containing 50,000 units of vitamin D, weekly for 6 to 8 weeks. Then the findings of before and after the intervention were evaluated.
Results: The mean age of the patients was 34.7 ± 8.58 years. 31 (59.6%) cases were women. The overall mean Anti-TPO titer of the patients after 6-8 weeks of the intervention significantly decreased compared to the beginning of the study (90.22±119.1 IU/ml versus 103.4±133.51 IU/ml). There was no association between changes in Anti TPO antibody levels with age, gender and body mass index (P>0.05).
Conclusion: Our study showed that in patients with Hashimoto's thyroiditis, taking vitamin D supplements for more than 6 to 8 weeks can be significantly associated with a decrease in Anti-TPO titer. It seems necessary to assess the level of vitamin D and prescribe it to reduce the exacerbation of symptoms in patients.
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| Keywords: Hashimoto's thyroid, Vitamin D, Anti TPO titer |
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Full-Text [PDF 766 kb]
(13 Downloads)
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Semi-pilot: Quazi-Experimental |
Subject:
Metabolism and Endocrinology
Received: 2024/06/2 | Accepted: 2024/10/2 | Published: 2025/05/31
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