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:: Volume 21, Issue 1 (spring 2011) ::
MEDICAL SCIENCES 2011, 21(1): 1-6 Back to browse issues page
Effects of nicotine on sperm motility in male mice under methylphenidate treatment
Simin Fazelipour 1, Mahsa Hadipour-Jahromy2 , Zahra Tootian3 , Ladan Babaei4 , Seyed Babak Kiaei3
1- Islamic Azad University, Tehran, Iran , Simin_fazelipour@yahoo.com
2- Islamic Azad University, Tehran, Iran
3- University of Tehran, Tehran, Iran
4- Tehran Medical University, Tehran, Iran
Abstract:   (32033 Views)
Background: Nicotine is an important part of cigarette smoke with strong physical and psychological effects on smokers. Methylphenidate (mph) is a medicine that has been prescribed widely for treatment of attention deficit hyperactivity disorder (ADHD). In the present study, effects of both mph and nicotine on sperm motility which is one of the most effective factors in male fertility genital tract have been evaluated.
Materials and methods: In this experimental study, one hundred and twenty male mice divided in 11 treated and one control groups. In treated groups, mph with doses of 2 and 10 mg/kg and nicotine with doses of 100, 200 and 400 microgr/kg were prescribed separately and in combinations orally for 40 days. At the final day, mice were killed and percent of sperm motility was calculated by counting gametes present in vasodeferan. Data were analyzed using Kruskal-wallis, Post-Hoc (Scheffe) and student’s t-test. P<0.05 was considered significant.
Results: The sperm motility has been reduced significantly in groups that received both mph and nicotine.
Conclusion: it can be concluded that even in light smokers, mph administration at high amount can reduce sperm motility.
Keywords: Methylphenidate, Nicotine, Sperm motility, Mice
Keywords: Methylphenidate, Nicotine, Sperm motility, Mice
Full-Text [PDF 469 kb]   (3636 Downloads)    
Semi-pilot: Experimental | Subject: Physiology
Received: 2011/06/25 | Published: 2011/06/15
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fazelipour S, Hadipour-Jahromy M, Tootian Z, Babaei L, Kiaei S B. Effects of nicotine on sperm motility in male mice under methylphenidate treatment. MEDICAL SCIENCES 2011; 21 (1) :1-6
URL: http://tmuj.iautmu.ac.ir/article-1-417-en.html


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Volume 21, Issue 1 (spring 2011) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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