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:: Volume 31, Issue 2 (summer 2021) ::
MEDICAL SCIENCES 2021, 31(2): 156-163 Back to browse issues page
The effect of curcumin on altered expression of BAX and BCL2 genes following cholestasis in the frontal region of male rats
Shabnam Akbari1, Mohammad Nasehi 2, Mehrdad Hashemi3
1- MSc,Department of Genetics,Tehran Medical Sciences,Islamic Azad University,Tehran,Iran
2- Associate Professor,Department of Physiology,Institute for Cognitive Science Studies(ICSS),Tehran Medical Sciences, Islamic Azad University, Tehran, Iran , Nasehi@iricss.org
3- Professor,Department of Genetics,Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Abstract:   (562 Views)
Background: Cholestasis occurs as a result of malfunction or secretion of bile; and complications of this disease include apoptosis (planned death). Curcumin is an effective extract of turmeric rhizome that has anti-apoptosis properties. Thus in this study, we investigated the expression of BAX and BCL2 genes following cholestasis and curcumin in the frontal region of male rats.
Materials and methods: This study was performed on 16 male rats weighing 220-240 gram in which they were divided into 4 groups, including control group, sham-curcumin, BDL group and BDL-curcumin. Then peripheral region of rats was collected and after extraction of RNA and cDNA synthesis, expression of genes in different groups was evaluated by Real Time PCR technique.
Results: BCL2 gene expression decreased in the BDL group compared to the control group(p<0.05), and BAX gene expression increased in the BDL group compared to the control group as a result,the cell progresses to apoptosis. However,with the injection of curcumin,the expression of BCL2 gene in the BDL-Curcumin group increased compared the BDL group and BAX gene expression decreased  in the BDL-Curcumin compared to the BDL group.
Conclusion: Curcumin can increase the expression of BCL2 gene and decrease the expression of BAX gene in the frontal region,reduce the negative effects of cholestasis including apoptosis.
Keywords: Cholestasis, Bax, Bcl2, Curcumin, Frontal
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Semi-pilot: Basic | Subject: Brain and Nerves System
Received: 2020/06/16 | Accepted: 2021/01/10 | Published: 2021/06/22
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Akbari S, Nasehi M, Hashemi M. The effect of curcumin on altered expression of BAX and BCL2 genes following cholestasis in the frontal region of male rats. MEDICAL SCIENCES. 2021; 31 (2) :156-163
URL: http://tmuj.iautmu.ac.ir/article-1-1708-en.html


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Volume 31, Issue 2 (summer 2021) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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