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:: Volume 26, Issue 3 (fall 2016) ::
MEDICAL SCIENCES 2016, 26(3): 135-141 Back to browse issues page
Study of histometric and histopathologic changes and biochemical functioning of liver in mice Balb/C treated with methylphenidate
Niousha Jamshidi Tari1 , Simin Fazelipoor 2, Ali Looie Monfared3 , Zahra Tootian4
1- Medical Student Tehran Medical sciences Branch, , Islamic Azad University, Tehran, Iran
2- Department of Anatomy, Tehran Medical sciences Branch, , Islamic Azad University, Tehran, Iran , Simin_fazelipour@yahoo.com
3- Department of Basic Sciences, Faculty of Para-veterinary, Ilam University, Ilam, Ir
4- Department of Basic Sciences, Faculty of Veterinary, Tehran University, Tehran, Iran
Abstract:   (6025 Views)

Background: Methylphenidate or ritalin is one of the brain stimulant drug and used in treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy and situational tachycardia syndrome. In the present survey, the effect of methylphenidate on the liver was studied.

Materials and methods: In this experimental study, a total of 24 male mice were randomly divided into three groups, including one control and two experimental groups. In experimental groups, ritalin was used in the doses of 2 and 10 mg/kg by gavages method for 40 days. At the end of the period and after animals’ euthanasia, the livers specimens were removed. Then, histological changes were studied using a light microscope. Also, blood sera were collected and the hepatic enzymes activity was determined. The data were statistically analyzed by ANOVA test and the p<0.05 was considered as significant.

Results: Administration of methylphenidate in different concentrations resulted in significant reduction of hepatocytes diameters, decrease in nuclei diameters, increase in the size of hepatic sinusoids, and also necrosis and congestion in central vein. Furthermore, in the liver parenchyma belonging to treated groups, the infiltration of mononuclear leukocytes was observed. In the treated groups, the activity of the hepatic enzymes showed a significant increase compared with the control group.

Conclusion: Considering the present findings, it could be suggested to avoid of prescribing of methylphenidate, especially in the patients with hepatic failures.

Keywords: Methylphenidate, Enzyme, Liver, Mouse.

Keywords: Methylphenidate, Enzyme, Liver, Mouse.
Full-Text [PDF 569 kb]   (1920 Downloads)    
Semi-pilot: Experimental | Subject: Anatomy
Received: 2016/01/19 | Accepted: 2016/04/13 | Published: 2016/09/17
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Jamshidi Tari N, Fazelipoor S, Looie Monfared A, Tootian Z. Study of histometric and histopathologic changes and biochemical functioning of liver in mice Balb/C treated with methylphenidate. MEDICAL SCIENCES 2016; 26 (3) :135-141
URL: http://tmuj.iautmu.ac.ir/article-1-1127-en.html


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Volume 26, Issue 3 (fall 2016) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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