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The protective effect of ethanol extract of ginger (Zingiber officinale) on spermatogenesis toxicity induced by doxorubicin
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Fatemeh Juibar1   , Mokhtar Mokhtari2 , Mehdi Dianatpur3 , Mehrdad Shariatie4 |
1- PhD student, Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran
2- Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran , M.Mokhtari246@yahoo.com
3- Department of Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4- Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran |
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Abstract: (5581 Views) |
| Background: DOX is one of the most common drugs used to treat different types of cancer, including testicular cancer. The aim of this study was to evaluate the effect of ethanol extract of ginger on spermatogenesis in rats.
Materials and methods: In this experimental study, 56 male rats Wistar were randomly divided into 6 groups of 8 animals control, the sham and experimental group 1 receiving doxorubicin (mg/kg.bw 3) experimental 2 and 3 receiving ginger extract (500 , 1000 mg/ kg. bw ) and experimental 4 and 5 received a ginger extract (500 , 1000 mg/ kg. bw ) + doxorubicin. The rats were fed extract daily, one hour after doxorubicin injection, for four weeks. DOX (3mg/kg) was administered once a week intraperitoneally. Some sperm parameters, such as the number, viability, morphology and mobility were examined using Eosin-Ngrozin staining.
Results: A significant decrease in body weight, sperm count, sperm motility, viability was observed in drug-DOX-treated rats compared with the control group. The reduction in the group treated with DOX with ginger 500 and 1000 mg/ kg significantly was offset compared with DOX.
Conclusion: Ginger is able to have protective effect on sperm parameters in adult male rat induced by Doxorobicin.
Keywords: Ginger, Doxorubicin, Body weight, Testes, Sperm parameters, Rat. |
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| Keywords: Ginger, Doxorubicin, Body weight, Testes, Sperm parameters, Rat. |
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Full-Text [PDF 409 kb]
(1525 Downloads)
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Semi-pilot: Experimental |
Subject:
Physiology
Received: 2016/11/14 | Accepted: 2016/11/22 | Published: 2017/06/19
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