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:: Volume 31, Issue 3 (Fall 2021) ::
MEDICAL SCIENCES 2021, 31(3): 284-289 Back to browse issues page
Preparation and in-vitro evaluation of sustained release glatiramer solid lipid nanoparticles
Fatemeh Ghashghaee1 , Solmaz Ghaffari 2
1- Department of Medical Chemistry, Faculty of Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2- 2Department of Pharmaceutics, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran 3 Dental Material Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran , soligh@yahoo.com
Abstract:   (2242 Views)
Background: Multiple sclerosis (MS), which is associated with the destruction of the myelin of the nerve cells, causes many motor-sensory problems and disrupts their quality of life. One of the remedies for this disease is glatiramer, which is injected daily as a peptide at a dose of 20 mg, tolerating of it for a long period of time is too difficult due to irritation of injection site. In this study with using nanotechnology tried to control the release rate of the drug to increase the interval of injections and consequently, patient’s tolerance.
Materials and methods: Glatiramer solid lipid nanoparticles (SLNs) were prepared using cholesterol as carrier by high shear homogenization technique. The particle size and zeta potential were investigated. The particle morphology was evaluated by SEM (Scanning Electron Microscopy) and finally the drug loading efficacy and drug release pattern were studied. To enhance the stability of the prepared nanoparticles, lyophilization was carried out by mannitol as cryoprotectant agent.
Results: The results showed that particles prepared with a size less than 300 nm and PDI: Polydispersity Index of less than 0.5, drug loading rate of over 74% and release over 6 days could be a good candidate for replacement of current treatment with this drug.
Conclusion: It seems that drug delivery of glatiramer with nanotechnology could provide a new solution for the problem of controlling MS with this drug in the future with more patient compliance.
Keywords: Multiple sclerosis, Nanotechnology, Glatiramer, Sustained release, Side Effects.
Full-Text [PDF 261 kb]   (1562 Downloads)    
Semi-pilot: Experimental | Subject: Pharmacology
Received: 2020/01/22 | Accepted: 2020/06/1 | Published: 2021/09/1
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Ghashghaee F, Ghaffari S. Preparation and in-vitro evaluation of sustained release glatiramer solid lipid nanoparticles. MEDICAL SCIENCES 2021; 31 (3) :284-289
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Volume 31, Issue 3 (Fall 2021) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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