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:: Volume 32, Issue 3 (Fall 2022) ::
MEDICAL SCIENCES 2022, 32(3): 293-302 Back to browse issues page
The effect of Gallic acid on prenatal entorhinal cortex and CA1/CA3 hippocampal areas in trimethyltin intoxication rat
Razieh Raghebi1 , Soheila Mohammadi Safari Kuchi2 , Mahboobeh Karimi2 , Mohammad Amin Edalatmanesh 3
1- MSc in Cell and Developmental Biology, Department of Biology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran
2- MSc in Animal Physiology, Department of Biology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran
3- Department of Biology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran , amin.edalatmanesh@gmail.com
Abstract:   (154 Views)

Background: Prenatal intoxication with trimethyletin (TMT) induces widespread neuronal death in the central nervous system by inducing oxidative stress. The aim of this study was to evaluate the antioxidant effect of gallic acid (GA) on the neuronal density of the entorhinal cortex, hippocampal pyramidal cells and oxidative stress parameters in the fetal forebrain following TMT intoxication.
Materials and methods: 25 pregnant Wistar female rats were randomly divided into 5 groups, including control, TMT+Saline, TMT+GA100, TMT+GA200 and TMT+GA400. To induce TMT intoxication, TMT (9 mg/kg body weight) was injected intraperitoneally into pregnant rats on embryonic day (ED) 14. From the ED12 to ED18, the treatment groups received orally GA at different doses. After fetal cesarean section on the ED21, neuronal density assessment of the entorhinal cortex, CA1 and CA3 regions of the hippocampus and forebrain level of catalase (CAT), superoxide dismutase (SOD) and malondialdehyde (MDA) was performed by ELISA.
Results: The results showed a significant increase in the activity of CAT and SOD enzymes and a significant decrease in MDA in the forebrain of GA-receiving groups compared to the TMT + Saline group. In addition, increased neuronal density was observed in the entorhinal cortex and CA1/CA3 regions of the hippocampus in the GA treated rats compared to the TMT + Saline group.
Conclusion: Prenatal TMT intoxication induced oxidative stress in the fetal forebrain, causing damage to the entorhinal cortex and hippocampus of rat fetal brain. On the other hand, GA prevented and improved neuronal damage in these areas of the fetal brain.
 
Keywords: Entorinal cortex, Hippocampus, Trimethylettin, Prenatal, Gallic acid
Full-Text [PDF 590 kb]   (51 Downloads)    
Semi-pilot: Experimental | Subject: Animal Biology
Received: 2022/02/24 | Accepted: 2022/04/19 | Published: 2022/09/19
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Raghebi R, Mohammadi Safari Kuchi S, Karimi M, Edalatmanesh M A. The effect of Gallic acid on prenatal entorhinal cortex and CA1/CA3 hippocampal areas in trimethyltin intoxication rat. MEDICAL SCIENCES 2022; 32 (3) :293-302
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Volume 32, Issue 3 (Fall 2022) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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