1- Assistant Professor, Department of Oral and Maxillofacial Medicine, School of Dentistry, Qom University of Medical Sciences, Qom, Iran 2- Assistant Professor, Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran 3- Assistant Professor of Pharmaceutical Chemistry, Department of Physiology and Pharmacology, School of Medicine, Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran 4- Dentistry Student, School of Dentistry, Qom University of Medical Sciences, Qom, Iran , alavighazal77@gmail.com 5- Dentist, School of Dentistry, Qom University of Medical Sciences, Qom, Iran
Abstract: (26 Views)
Background: This study investigated the antimicrobial effects of aqueous and ethanolic extracts of Oliveria decumbens on Streptococcus mutans and Lactobacillus acidophilus, which are key contributors to dental caries. Considering the relative resistance of these bacteria to antibiotics and the traditional use of medicinal plants, this study was conducted to evaluate these effects. Materials and methods: The plant extracts were prepared using the maceration method and serial dilutions. Standard bacterial strains were obtained from reliable sources and cultured in appropriate media. Aqueous and ethanolic extracts were added to bacterial suspensions in microplate wells and incubated anaerobically at 37°C for 48 hours. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined through visual observation. Results: The aqueous extract inhibited the growth of both bacterial species at concentrations of 2048, 1024, and 512 µg/ml, with an MIC of 512 µg/ml. Additionally, the aqueous extract exhibited bactericidal activity at concentrations of 2048 and 1024 µg/ml, with an MBC of 1024 µg/ml. On the other hand, the ethanolic extract showed no antimicrobial activity at any concentration. Conclusion: This study demonstrates that the aqueous extract of the plant has moderate antimicrobial effects, whereas the ethanolic extract exhibited no activity.
Barkian Y, Fateh R, Abolhasani H, Alavi G, Reiszadeh A, Amouzad Z. Antibacterial activity of Oliveria decumbens extract on Streptococcus mutans and Lactobacillus acidophylus. MEDICAL SCIENCES 2025; 35 (3) :286-293 URL: http://tmuj.iautmu.ac.ir/article-1-2280-en.html