1- Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran - Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran 2- Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran-Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran 3- Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran-Health Research Center, Chamran Hospital, Tehran, Iran 4- Department of Physiology, Tehran University of Medical Sciences, Tehran, Iran 5- Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran 6- Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran 7- Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran , D.siadat@gmail.com
Abstract: (31 Views)
Sepsis is a systemic inflammatory reaction caused by infection. Severe sepsis can lead to multiple organ dysfunction, with high incidence and mortality. Nearly 500,000 cases of sepsis occur in the United States, causing 80,000 deaths annually. Septic shock is a subset of sepsis and is a fatal condition. Despite significant advances for treating this disorder, the mortality rate of sepsis remains high. Numerous studies have shown the important role of bacterial extracellular vesicles in cancers, neurodegenerative disorders, diabetes, viral infections, autoimmune and kidney diseases. Also, bacterial extracellular vesicles have recently received attention due to their effective help in the diagnosis and management of sepsis. In recent years, studies on the role of bacterial extracellular vesicles in inflammatory diseases have shown that they have a dual role in the imbalance of the inflammatory response in sepsis. Extracellular vesicles in sepsis can be beneficial or harmful, depending on their origin and content. These vesicles have also been considered mediators of cell death and inflammation during conditions such as sepsis. This review comprehensively reviews studies investigating the role of bacterial extracellular vesicles in the pathogenesis, management, and treatment of sepsis.
Salmeh E, Soroush E, Soltanipur M, Yarmohammadi H, Rezaei M, Hafazeh L, et al . Bacterial extracellular vesicles in sepsis: from diagnosis to treatment. MEDICAL SCIENCES 2025; 35 (3) :241-257 URL: http://tmuj.iautmu.ac.ir/article-1-2312-en.html