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:: دوره 35، شماره 3 - ( پاییز 1404 ) ::
جلد 35 شماره 3 صفحات 257-241 برگشت به فهرست نسخه ها
وزیکول‌های خارج سلولی باکتریایی در سپسیس : از تشخیص تا درمان
الهه سال مه1 ، عرفان سروش1 ، مسعود سلطانی پور2 ، حسین یار محمدی2 ، مهدی رضایی3 ، لیلا حفذه4 ، ابوالفضل فاتح5 ، سید محسن میرحسینی6 ، سید داور سیادت7
1- بخش سل و تحقیقات ریوی، مرکز تحقیقات میکروبیولوژی، انستیتو پاستور ایران، تهران، ایران - دانشکده علوم تخصصی دامپزشکی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران
2- بخش سل و تحقیقات ریوی، مرکز تحقیقات میکروبیولوژی، انستیتو پاستور ایران، تهران، ایران ، تهران، ایران-مرکز تحقیقات قلب و عروق، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران
3- بخش سل و تحقیقات ریوی، مرکز تحقیقات میکروبیولوژی، انستیتو پاستور ایران، تهران، ایران- مرکز تحقیقات سلامت، بیمارستان چمران، تهران، ایران
4- گروه فیزیولوژی، دانشگاه علوم پزشکی تهران، تهران، ایران
5- بخش سل و تحقیقات ریوی، مرکز تحقیقات میکروبیولوژی، انستیتو پاستور ایران، تهران، ایران
6- مرکز تحقیقات قلب و عروق، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران
7- بخش سل و تحقیقات ریوی، مرکز تحقیقات میکروبیولوژی، انستیتو پاستور ایران، تهران، ایران ، D.siadat@gmail.com
چکیده:   (251 مشاهده)
سپسیس نوعی واکنش التهابی سیستمیک ناشی از عفونت است. سپسیس شدید می‌تواند منجر به اختلال عملکرد ارگان‌های متعدد، با میزان بروز و مرگ و میر بالا شود. سالانه نزدیک به 500 هزار مورد سپسیس در ایالات متحده امریکا رخ می‌دهد که موجب مرگ 80 هزار نفر در سال می‌شود. شوک سپتیک، زیر مجموعه سپسیس، یک وضعیت کشنده است. علیرغم پیشرفت‌های قابل توجه در درمان این بیماری، میزان مرگ و میر ناشی از سپسیس همچنان بالا است. تحقیقات متعدد نقش مهم وزیکول‌های خارج سلولی باکتریایی را در سرطان‌ها، اختلالات نورودژنراتیو، دیابت، عفونت‌های ویروسی، بیماری‌های خود ایمنی نشان داده­اند. هم‌چنین وزیکول‌های خارج سلولی باکتریایی اخیراً به دلیل کمک مؤثرشان در تشخیص و مدیریت سپسیس مورد توجه قرار گرفته‌اند. در سال‌های اخیر، با مطالعه نقش وزیکول‌های خارج سلولی باکتریایی در بیماری‌های التهابی، مشخص شده است که آن‌‌ها نقش دوگانه‌ای در عدم تعادل پاسخ التهابی در سپسیس دارند. وزیکول‌‌های خارج سلولی در سپسیس بسته به منشأ و محتویات آن‌ها می‌توانند همزمان مفید و مضر باشند. هم‌چنین این وزیکول‌ها به عنوان واسطه مرگ سلولی و التهاب در طی شرایطی مانند سپسیس مورد توجه قرار گرفته­اند. این مطالعه مروری به هدف مرور گسترده مطالعات به بررسی نقش وزیکول‌های خارج سلولی باکتریایی در پاتوژنز، مدیریت و درمان سپسیس می‌پردازد.
واژه‌های کلیدی: وزیکول خارج سلولی باکتریایی، سپسیس، پاسخ‌های التهابی
متن کامل [PDF 1104 kb]   (98 دریافت)    
نيمه آزمايشي : مروري | موضوع مقاله: بيماريهاي عفوني
دریافت: 1403/7/18 | پذیرش: 1403/10/8 | انتشار: 1404/6/10
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Salmeh E, Soroush E, Soltanipur M, Yarmohammadi H, Rezaei M, Hafazeh L, et al . Bacterial extracellular vesicles in sepsis: from diagnosis to treatment. MEDICAL SCIENCES 2025; 35 (3) :241-257
URL: http://tmuj.iautmu.ac.ir/article-1-2312-fa.html

سال مه الهه، سروش عرفان، سلطانی پور مسعود، یار محمدی حسین، رضایی مهدی، حفذه لیلا، و همکاران.. وزیکول‌های خارج سلولی باکتریایی در سپسیس : از تشخیص تا درمان. فصلنامه علوم پزشکی دانشگاه آزاد اسلامی تهران. 1404; 35 (3) :241-257

URL: http://tmuj.iautmu.ac.ir/article-1-2312-fa.html



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