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:: Volume 29, Issue 1 (spring 2019) ::
MEDICAL SCIENCES 2019, 29(1): 48-55 Back to browse issues page
Evaluation of serum levels of antioxidant trace elements, zinc, copper, selenium and manganese, in children with acute lymphoblastic leukemia before treatment
Mehrnaz Keshavarzi1 , Fariba Faraji 2, Monireh Movahedi3
1- MSc of Biochemistry, Department of Biochemistry, Faculty of Biology, Tehran North Branch, Islamic Azad University, Tehran, Iran
2- Department of Biochemistry, Faculty of Medicine, Tehran Medical sciences, Islamic Azad University, Tehran, Iran , faraji_fariba@hotmail.com
3- Department of Biochemistry, Faculty of biology, Tehran North Branch, Islamic Azad University, Tehran, Iran
Abstract:   (3824 Views)
Background: Reactive oxygen species (ROS) can induce carcinogenesis via DNA injury. Antioxidants participate in cell protection against harmful influence of oxidative stress. The aim of the present study was to assess the levels of antioxidant elements, including Zn, Cu, Se and Mn, in serum of children with acute lymphoblastic leukemia before treatment.
Materials and methods: In this study, 20 children just diagnosed ALL before chemotherapy (mean age, 6.6±4.6) compared to 20 healthy controls (mean age, 10.3±2.7). Concentration of the elements were measured with atomic absorption spectroscopy
Results: serum levels of Mn were significantly lower in acute leukemia than in controls (P=0.03), while Cu was significantly elevated (P <0.0001). There were no significant difference regarding Zn and Se between two groups (P =0.07 and P =0.35, respectively).
Conclusion: Based on obtained results, changes of serum level of these antioxidants could likely have biological role in initiation or progression of leukemia.  Further studies are needed to clarify the role of these factors in pathogenesis of acute leukemia
Keywords: Antioxidant trace elements, Acute lymphoblastic leukemia.
Full-Text [PDF 357 kb]   (2225 Downloads)    
Semi-pilot: Survey/Cross Sectional/Descriptive | Subject: Cilinical Biochemistry
Received: 2018/07/15 | Accepted: 2018/09/16 | Published: 2019/03/11
References
1. Battisti V, Maders LD, Bagatini MD, Santosa KF, Rosélia M, Spanevello B, et al. Measurement of oxidative stress and antioxidant status in Acute lymphoblastic leukemia patients. Clin Biochem 2008;41:511-8. [DOI:10.1016/j.clinbiochem.2008.01.027] [PMID]
2. Mehdi WA, Yusof F, Mehde AA, Zainulabdeen JA, Raus RA, Abdulbari AS. Effects of Acute Lymphoblastic Leukemia on Ceruloplasmin Oxidase, Copper and Several Markers of Oxidative Damage,in Children. Asian Pac J Cancer Prev 2015;16:5205-10. [DOI:10.7314/APJCP.2015.16.13.5205] [PMID]
3. Hadi N, Moezi M, Etehadi H. Investigation of risk factors of acute leukemia in children below 15 years in Shiraz. Daneshvar Journal 2007;67. [In Persian]
4. Baradaran B, Tartibian B, Baghaiee B, Monfaredan A. Correlation between superoxide dismutase 1 gene expression with lactate dehydrogenase enzyme and free radicals in female athletes: effects of incremental intensity exercises. Tehran Univ Med J 2012;4:212-9. [In Persian]
5. Diaz de Barboza G, Guizzardi S, Moine L, Tolosa de Talamoni N. Oxidative stress, antioxidants and intestinal calcium absorption. World J Gastroenterol 2017;23:2841-53. [DOI:10.3748/wjg.v23.i16.2841] [PMID] [PMCID]
6. Mazdak H, Mirkheshti N, Movahedian A, Yazdekhasti F, Behzad E, Shafieian M, et al. The study of the serum manganese concentration in the bladder cancer patients in comparison with healthy subjects. J Isfahan Med Sch 2008;26:267-72.
7. Salmani Nodoushan MH, Abedi M, Vakilli M. Selenium and Human Health. Shahid Sadoughi Univ Med Sci 2013;21:101-12. [In Persian]
8. Joshaghani H, Mirkarimi H, Besharat S, Roshandel Gh, SanaeiO, Nejabat M. Comparison of the Serum Levels of Trace Elements in Areas with High or Low Rate of Esophageal Cancer. Middle East J Dig Dis 2017;9:81-5. [DOI:10.15171/mejdd.2017.55] [PMID] [PMCID]
9. Zarghami N, Asadi J, Mahbob S, Mohammadzadeh G, Mohajeri A. Serum Levels of Se, Zn, Cu and Cu / Zn Ratio in Iranian Breast Cancer Patients. J Pharm Sci 2008;1:27-32. [In Persian]
10. El-Sabagh ME, Ramadan KS, El-slam IMA, Ibrahim AM. Antioxidants Status in Acute Lymphoblastic Leukemia Patients. American Journal of Medicine and Medical Sciences 2011;1:1-6. [DOI:10.5923/j.ajmms.20110101.01]
11. Skrzydlewska E, Sulkowski S, Koda M, Zalewski B, Kanczuga Koda L, Sulkowska M. Lipid peroxidation and antioxidant status in colorectal cancer. World J Gastroenterol 2005;11:403-6. [DOI:10.3748/wjg.v11.i3.403] [PMID] [PMCID]
12. Assi S, Ryaidh Sh. Al Husain: Study of Protective effect of Glutathione Peroxidase (GSH-Px), Vitamin E and Selenium on Iraqi children with Leukemia. J Biotechnol Res 2014;8:4.
13. Rezaeyan A, Haddadi GH, Hosseinzadeh M. Evaluating Superoxide Dismutase (SOD), Glutathione (GSH), Malondialdehyde (MDA) and the Histological Changes of the Lung Tissue after γ-Irradiation in Rats. J Fasa Univ Med Sci 2016;6:235-45. [In Persian]
14. Feng Zh, Wenwei Hu, Moon-shong Tang. Trans-4-hydroxy-2-nonenal inhibits nucleotide excision repair in human cells: A possible mechanism for lipid peroxidation-induced carcinogenesis. Proc Natl Acad Sci U S A 2004;101:8598-602. [DOI:10.1073/pnas.0402794101] [PMID] [PMCID]
15. Martín-Lagos F, Navarro-AlarcónC M, Terrés-MartosH C, López-G de la Serrana H, López-Martínez MC. Serum copper and zinc concentrations in serum from patients with cancer and cardiovascular disease. Sci Total Environ 1997;204:27-35. [DOI:10.1016/S0048-9697(97)00163-0]
16. Sgarbieri UR, Fisberg M, Tone LG, Latorre Mdo R. Nutritional assessment and serum zinc and copper concentration among children with acute lymphocytic leukemia. Sao Paulo Med J 2006;124:316-20. [DOI:10.1590/S1516-31802006000600003] [PMID]
17. Mazdak H, Mirkheshti N, Movahedian A, Yazdekhasti F, Behzad E, Shafieian M. The study of the serum iron,copper and zinc concentration in the bladder cancer patients in comparison with healthy subjects. J Isfahan Med Sch 2010;1:56-60. [In Persian]
18. DemirC, Demir H, Esen R, Sehitogullari A, Atmaca Alay M. Altered Serum Levels of Elements in Acute Leukemia Cases in Turkey. Asian Pac J Cancer Prev 2012;12:3471-4.
19. Elradi MMM. Investigation of Selected Trace Elements in Sudanese Patients with Leukemia using NAA. Sudan Academy of Sciences (SAS) Atomic Energy Council. 2010.
20. Eby GA. Treatment of acute lymphocytic leukemia using zinc adjuvant witchemotherapy and radiation-a case history and hypothesis. Med Hypotheses 2005;64:1124-6. [DOI:10.1016/j.mehy.2004.12.019] [PMID]
21. Mikac-Dević M, Ferenec D, Tiefenbach A. J Trace Elem Electrolytes Health Dis 1990;4:7-10.
22. Pazirandeh A, AssadiNejad M, Vossogh P. Determination of Selenium in Blood Serum of Children with Acute Leukemia and Effect of Chemotherapy on Serum Selenium Level. J Trace Elem Med Biol 1999;13:242-6. [DOI:10.1016/S0946-672X(99)80043-1]
23. Rasool M, Farooq S, Malik A, Shaukat A, Manan A, Asif M, et al. Assessment of circulating biochemical markers and antioxidative status in acute lymphoblastic leukemia (ALL) and acute myeloid leukemia(AML) patients. Saudi J Biol Sci 2015;22:106-11. [DOI:10.1016/j.sjbs.2014.09.002] [PMID] [PMCID]
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Keshavarzi M, Faraji F, Movahedi M. Evaluation of serum levels of antioxidant trace elements, zinc, copper, selenium and manganese, in children with acute lymphoblastic leukemia before treatment . MEDICAL SCIENCES 2019; 29 (1) :48-55
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Volume 29, Issue 1 (spring 2019) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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