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:: Volume 31, Issue 4 (WINTER 2021) ::
MEDICAL SCIENCES 2021, 31(4): 377-387 Back to browse issues page
Optimized preconcentration of Imatinib using dispersive liquid-liquid microextraction coupled with HPLC-UV
Pegah Poormand1 , Mahnaz Qomi 2, Javad Hosseini3
1- Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2- Active Pharmaceutical Ingredients Research Center (APIRC), Tehran Medical Sciences, Islamic Azad University, Tehran, Iran - Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran- Department of Applied Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran , mahnaz.qomi@gmail.com
3- Department of Applied Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Abstract:   (260 Views)
Background: Imatinib is an antineoplastic agent acting as a tyrosine kinase inhibitor to treat cancer such as lymphoblastic leukemia. The dosage of the anticancer drugs plays a critical role in the survival of the patients. For this reason, the patient's plasma and urine samples should be monitored to obtain the necessary information regarding the toxicity of the drug. In this study, the applicability of preconcentration and dispersive liquid-liquid microextraction for extraction of trace amount of Imatinib in aqueous samples, before a determination by High-Performance Liquid Chromatography (HPLC), was evaluated.
Materials and methods: The targeted drug was extracted from an aqueous sample with pH= 11 (the donor phase) into an extraction solvent (n-octanol) in the dispersive solution (acetone) as an acceptor phase, which has been dispersed in the sample solution. Different variables on extraction efficiency were studied and optimized by chemometrics design and the Taguchi method. The variables were the donor phase's pH, type of extraction solvent, type of dispersive solvent, speed stirring, extraction time, and extraction temperature.
Results: The optimum conditions of the test were as pH of donor phase:11, type of extraction solvent: n-octanol, type of dispersive solvent: acetone, speed stirring: 500rpm , extraction time: 45min,  extraction temperature: 65 centigrade.
Conclusion: The developed method was simple, rapid, sensitive, and suitable for determining trace amounts of Imatinib in aqueous samples.
Keywords: High-performance liquid chromatography, Dispersive liquid-liquid microextraction, Preconcentration, Imatinib.
Full-Text [PDF 372 kb]   (94 Downloads)    
Semi-pilot: Experimental | Subject: Chemistry
Received: 2020/05/9 | Accepted: 2021/08/4
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Poormand P, Qomi M, Hosseini J. Optimized preconcentration of Imatinib using dispersive liquid-liquid microextraction coupled with HPLC-UV. MEDICAL SCIENCES. 2021; 31 (4) :377-387
URL: http://tmuj.iautmu.ac.ir/article-1-1706-en.html


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Volume 31, Issue 4 (WINTER 2021) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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