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جلد 32 شماره 4 صفحات 346-337 برگشت به فهرست نسخه ها
مروری بر نقش عوامل ژنتیکی میزبان در ابتلا به SARS-CoV-2
فاطمه کرمی1 ، محمدحسین مدرسی 2
1- گروه ژنتیک پزشکی، مرکز تحقیقات کاربردی بیوفتونیک، دانشگاه آزاد اسلامی، واحد علوم و تحقیقات تهران، ایران
2- گروه ژنتیک پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی تهران، تهران، ایران ، modaresi@tums.ac.ir
چکیده:   (116 مشاهده)
سابقه و هدف: همه گیری سندرم حاد تنفسی شدید نوع 2 (SARS-CoV-2) بیش از یک سال است که تمام مردم دنیا را درگیر کرده است. بروز و شدت متفاوت این بیماری ویروسی در بین سنین مختلف و افراد با زمینه­های متفاوت بیماری می­تواند بیانگر نقش مهم عوامل ژنتیکی میزبان در میزان شیوع و مرگ و میر آنها باشد. به همین منظور مطالعه حاضر جهت مرور بر مهم­ترین عوامل و   واریانت­های ژنتیکی دخیل در بروز و شدت بیماری SARS-CoV-2 مطابق مطالعات انجام شده در جمعیت­های مختلف انجام شد.
روش بررسی: پایگاههای اطلاعاتی شاملGoogle Scholar ،Bing ،PubMed Central ، PubMed،  medRxiv و COVID-19 host genetics initiative  با استفاده از واژه‌های کلیدی Gene، polymorphism،  disease severity، Infection risk ،Gene variant  و Gene expression برای یافتن مقالات مرتبط با فاکتورهای ژنتیکی همراه با  SARS-CoV-2  و شدت آن مورد جستجو قرار گرفت. 
یافته ها و نتیجه گیری: به نظر می­رسد علاوه بر واریانت­های سیستم HLA و ژن­های مرتبط با اینترفرون­ها نظیر IFITM3، ژن­های TMPRSS2، ACE2، ACE،CD147 و TLR7 مهم­ترین ژن­های دخیل در بیماریزایی ویروس SARS-CoV-2 هستند. بررسی مهم­ترین واریانت­های این ژن­ها در جمعیت­های مختلف در همراهی با SARS-CoV-2 می­تواند راه را برای یافتن درمان­های هدفمندتر این بیماری فراهم آورد. به علاوه، با شناسایی این واریانت­ها می­توان در شناسایی سریع­تر حاملین پرخطر ویروس­های مشابه نسل­های بعدی گام­های موثرتری برداشت.
واژه‌های کلیدی: SARS-CoV-2، واریانت ژنی، پلی مورفیسم ژنی، شدت بیماری
متن کامل [PDF 328 kb]   (45 دریافت)    
نيمه آزمايشي : مروري | موضوع مقاله: ژنتيك
دریافت: 1400/12/16 | پذیرش: 1401/6/13 | انتشار: 1401/10/10
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Karami F, Modarressi M H. Review on the role of host genetic factors in the susceptibility to SARS-CoV-2. MEDICAL SCIENCES 2022; 32 (4) :337-346
URL: http://tmuj.iautmu.ac.ir/article-1-1989-fa.html

کرمی فاطمه، مدرسی محمدحسین. مروری بر نقش عوامل ژنتیکی میزبان در ابتلا به SARS-CoV-2. فصلنامه علوم پزشکی دانشگاه آزاد اسلامی تهران 1401; 32 (4) :346-337

URL: http://tmuj.iautmu.ac.ir/article-1-1989-fa.html



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دوره 32، شماره 4 - ( زمستان 1401 ) برگشت به فهرست نسخه ها
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